DRSC/TRiP Functional Genomics Resources

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Protein Alignment NHERF1 and nrfl-1

DIOPT Version :10

Sequence 1:NP_004243.1 Gene:NHERF1 / 9368 HGNCID:11075 Length:358 Species:Homo sapiens
Sequence 2:NP_741479.1 Gene:nrfl-1 / 177736 WormBaseID:WBGene00006438 Length:608 Species:Caenorhabditis elegans


Alignment Length:380 Identity:94/380 - (24%)
Similarity:147/380 - (38%) Gaps:84/380 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    11 LPRLCCLEKG--PNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKET-H 72
            ||||..|.||  ...:||:||.|:|: |.:|..|:.|...|||||.||.|:|.|||:.:...| |
 Worm   281 LPRLAELNKGTPDQEFGFNLHAERGR-GHFIGTVDAGGIGEKAGLEAGQRIVGVNGQLIYPTTGH 344

Human    73 QQVVSRIRAALNAVRLLVVDPETD------------EQLQKLGVQV--------REELLRAQEAP 117
            ::||:.|:.......|||...:.|            :.::::..:.        ..|.:...::.
 Worm   345 KEVVALIKKDTMKTTLLVASEDVDKYHKDHNIAYSWDNVERVDTRPVINVETHHHHEEVSVPKSN 409

Human   118 GQAEPPA---AAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFI 179
            |...||.   :.:|      ||.||..|     .....|..|:....|.|.:     |.....:.
 Worm   410 GYDVPPLNPHSIQV------NEEREISK-----MTTTTRTETITNSNSAYQY-----KESSTAYD 458

Human   180 RSVDPDSPAEASGLRAQDRI---VEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKK 241
            ....|  |.:::.|  .|.:   |.:.||.|  ..|.:|:.                .||:.   
 Worm   459 AYATP--PVDSNDL--MDEVFGRVNLPGVTM--SSHTEVLP----------------PTDDI--- 498

Human   242 CRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQ 306
            ..|.....|....:.||.         |.:.:...|.||.:.....|.:.....: :.|.||...
 Worm   499 SSVSSLSSHRESAVDVPV---------SHQYVPSYATESHQKHEQHSQTHHHHHQ-HQQPSPLSN 553

Human   307 DST---APSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL 358
            .|:   |.||||..|....:::|...|:||...|.......:|..::|.:|.||:
 Worm   554 GSSHGYAASSTSGYDDDDIYHLSAREARERLRMKNRKHHLHEMSLNEKYQLVSNM 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NHERF1NP_004243.1 PDZ_NHERF-like 13..92 CDD:467249 35/81 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..192 16/80 (20%)
PDZ_NHERF-like 153..232 CDD:467249 15/81 (19%)
EBP50_C 235..358 CDD:462654 30/125 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..358 23/83 (28%)
nrfl-1NP_741479.1 PDZ_NHERF-like 283..364 CDD:467249 35/81 (43%)

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