Protein Alignment RAB9A and Rab5

DIOPT Version :10

• Sequence 1: NP_004242.1
• Gene: RAB9A / 9367
• HGNCID: 9792
• Length: 201
• Species: Homo sapiens
• Sequence 2: NP_523457.1
• Gene: Rab5 / 33418
• FlyBaseID: FBgn0014010
• Length: 219
• Species: Drosophila melanogaster
• Alignment Length: 206
• Identity: 70/206 - (33%)
• Similarity: 110/206 - (53%)
• Gaps: 21/206 - (10%)

Human     4 KSSLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFVTMQIWDTAGQER 68
            ||..||::|||:..||||||:.|:|..:|......|||..||.:.:.::...|..:|||||||||
  Fly    26 KSCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTICIEDTVVKFEIWDTAGQER 90

Human    69 FRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFVIL---GNKIDISE 130
            :.||...:|||:...::.:.:.:..|||....|.||.       ..::.|.:::   |||.|:|.
  Fly    91 YHSLAPMYYRGAQAAIVVYDIQNQDSFQRAKTWVKEL-------HKQASPNIVIALAGNKADLSN 148

Human   131 -RQVSTEEAQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVLATEDRSDH----LIQTDTVNL 190
             |.|..:||:.:..:|| ..:.|||||...||...| .|:.:.|...|.:::    :..|.|
  Fly   149 IRVVEFDEAKQYAEENG-LLFMETSAKTGMNVNDIF-LAIAKKLPKNDGANNQGTSIRPTGT--- 208

Human   191 HRKPKPSSSCC 201
             ...:|:::||
  Fly   209 -ETNRPTNNCC 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB9A	NP_004242.1	Rab9	3..172	CDD:206697	63/171 (37%)
		Switch 1. /evidence=ECO:0000269|PubMed:34793709, ECO:0007744|PDB:7E1T	31..42		3/10 (30%)
		Switch 2. /evidence=ECO:0000269|PubMed:34793709, ECO:0007744|PDB:7E1T	64..78		7/13 (54%)
Rab5	NP_523457.1	Rab5_related	29..191	CDD:206653	61/170 (36%)