Protein Alignment RAB9A and Rab27

DIOPT Version :10

• Sequence 1: NP_004242.1
• Gene: RAB9A / 9367
• HGNCID: 9792
• Length: 201
• Species: Homo sapiens
• Sequence 2: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Alignment Length: 223
• Identity: 83/223 - (37%)
• Similarity: 115/223 - (51%)
• Gaps: 31/223 - (13%)

Human     1 MAGKSSLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDG----HFVTMQIW 61
            :||....|  ::|||.||||:.|:.:|...:|.||...|:|::|..|.|..:.    |.:.:|||
  Fly    13 LAGSGEQF--LVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIW 75

Human    62 DTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFVILGNKI 126
            |||||||||||.|.|||.:...||.|.:...:||...:||..:...:|..::|:   .|:.|||.
  Fly    76 DTAGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPD---VVLCGNKC 137

Human   127 DISE-RQVSTEEAQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVL-----ATEDRSDHLIQT 185
            |:.: |.||.::..|.|| ....||.||||....||..|.|..|.||:     |..:|...|:.|
  Fly   138 DLLQLRVVSRDQVAALCR-RYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLT 201

Human   186 --------------DTVNLH-RKPKPSS 198
                          |.|.|| |:.:|.|
  Fly   202 QSRCLPNIAYGQPEDLVRLHDRREEPCS 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB9A	NP_004242.1	Rab9	3..172	CDD:206697	69/173 (40%)
		Switch 1. /evidence=ECO:0000269|PubMed:34793709, ECO:0007744|PDB:7E1T	31..42		4/10 (40%)
		Switch 2. /evidence=ECO:0000269|PubMed:34793709, ECO:0007744|PDB:7E1T	64..78		11/13 (85%)
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	70/173 (40%)