Protein Alignment CADPS2 and Cadps

DIOPT Version :10

• Sequence 1: NP_001350318.1
• Gene: CADPS2 / 93664
• HGNCID: 16018
• Length: 1308
• Species: Homo sapiens
• Sequence 2: NP_001245439.1
• Gene: Cadps / 49968
• FlyBaseID: FBgn0053653
• Length: 1534
• Species: Drosophila melanogaster
• Alignment Length: 1507
• Identity: 790/1507 - (52%)
• Similarity: 1001/1507 - (66%)
• Gaps: 241/1507 - (15%)

Human     1 MLDPSSSEEESDE-----------------------------------------------GLEEE 18
            |:||||||||.::                                               |.:.:
  Fly     1 MIDPSSSEEEGEDDAVPNVSSKGRLTNTTKGTSAVSIIGGSAGSVVGSNIPVSGSNTDLIGNQRQ 65

Human    19 S--------RDV----LVAAGS---------------------SQRAPPAPTREGRRDAPGRAGG 50
            |        .||    :.|.||                     |...|...::|....:.|.:..
  Fly    66 SNISSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQETLNQSVGSSRA 130

Human    51 GGAARSVSPSPSVLSEGRD--EPQRQLD-DEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQ 112
            ....|.:|||||:.||..:  ||..:.: :|:||:.|:|||||:.|||:|||||||||||.:||.
  Fly   131 NSLPRPLSPSPSLTSEKHETAEPHGKHEREEEERKRRIQLYVFISRCISYPFNAKQPTDMTKRQT 195

Human   113 KLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVF 177
            |::||||:::.:||||||.|||||:|||||.|||:||::|||||:||.:|||||..|.:||||||
  Fly   196 KISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSGASSQHDFREVF 260

Human   178 KKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYR--GEEDLCKQPNRMALSAVSELILSKEQLY 240
            :.|||||||||||||||||||||:||:||:|.|.:  |||| .|:|:||..|..|||||||||||
  Fly   261 RNNIEKRVRSLPEIDGLSKETVLTSWMAKFDIILKGTGEED-SKRPSRMQQSLNSELILSKEQLY 324

Human   241 EMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLADKMAKERK-FPKFIAKDMENM 304
            :||||||.:||.|||:|:||..||:||||||.||||||||:|...:|.|.|| .|||:.|:||::
  Fly   325 DMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLMPKFVLKEMESL 389

Human   305 YIEELRSSVNLLMANLESLPVSKGGPEFK--LQKLKRSQNS--AFLDI------------GD--E 351
            |:|||:||:|||||||||||||||..:.|  ||||||..:|  :||.:            ||  :
  Fly   390 YVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHGSLSKLEGDSED 454

Human   352 NEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVE-GEKLQTDQAEASRPQWGTQGDF 415
            ...||:|.||||:|.||:::|||:||||:||||||||||||| ||||||||||||:|.|.|||||
  Fly   455 GSTQLTKLDVVLTFQLEVIVMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEASKPMWDTQGDF 519

Human   416 TTTHPRPVVKVKLFTESTGVLALEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAV 480
            |||||.|||||||:||:.|:|||||||||:|.|.||..||||.|.|||:||||..|.|::||:|.
  Fly   520 TTTHPLPVVKVKLYTENPGMLALEDKELGKVTLKPTPLSSKSPEWHRMIVPKNLPDQDIRIKIAC 584

Human   481 RMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDY 545
            |:|||.:|||.|||||:|:.|||:||:||||||||||||||||||:||||||.|:|||:||||||
  Fly   585 RLDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTVDY 649

Human   546 TDPHPG-------LQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQK 603
            .:....       |.||..|||||:|||::.||.|||.:..|||.|||||||||:||.|.| ||.
  Fly   650 IEAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMAMYRATGQSHKPTPPI-TQD 713

Human   604 LNPKGGTLHADAQLSGKDADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGW 668
            .|      .|.:::.| |||:.:||||::|||.:||..|||.||:.||..||::||||.|:.|||
  Fly   714 KN------SAMSKIQG-DADKARKHGMEDFISTDPCTFDHATLFKTLQNLTLEYRLNDPYASLGW 771

Human   669 FSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGI 733
            |||||||||||||||||||||:||||||::|::.:|...:|||||:||||||||||||||||||:
  Fly   772 FSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRAEKQHMIDPTLIHYSFAFCASHVHGNRPDGV 836

Human   734 GTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEE 798
            |:::.||||:|.||||||..|||.||::|||||||||||||||||||||||||||||.||:|.||
  Fly   837 GSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPPEE 901

Human   799 VKKVVRKCLEKAALINYTRLTEYAKIEGPAEKETETMNQASPA-RKLEEILHLAELCIEVLQQNE 862
            |:::::|.||.|||:|||||:..|||:     |....:...|| :|||:::||||||:::|||||
  Fly   902 VRQMIKKSLETAALVNYTRLSNKAKID-----EDLRGDVIVPAPKKLEDLIHLAELCVDLLQQNE 961

Human   863 EHHAEGRE--------------------------------------------------------- 870
            ||:.|.|:
  Fly   962 EHYGELRKHDKMDKKKLLKEDEDVSGGHNESEVDLIDSTGLISASELATAASTDGSSFRYCMPTH 1026

Human   871 ---------AFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTLLC 926
                     ||||:.|||.||||.||:||.||||..|..|..|:||||||||:||::||.|..|.
  Fly  1027 AVYTPPVPTAFAWFSDLLVEHAEIFWSLFAVDMDRVLSEQAPDTWDSFPLFQILNDYLRTDDNLR 1091

Human   927 NGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQ-----------PVKNIANSLPNVA 980
            ||:||:||::.|.|||||||||||||||||||:|||:|.|:           .:.|.|.:|...|
  Fly  1092 NGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKERWESKGINAALNPAALNNAAQALNTAA 1156

Human   981 LPKVPSLPL---------NLPQIPNISTASWMPSLYESTNGSATSEDLFWKLDALQMFVFDLHWP 1036
            |.  ||:.|         .:|::|..|.::  .:..|..||.||||||||||||||.|:.|||||
  Fly  1157 LN--PSMILCGKKDQVNFYVPKLPKQSNST--AANDEMRNGCATSEDLFWKLDALQSFIRDLHWP 1217

Human  1037 EQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQK--ASKTTDLRIPASVCTMFNVLVDAKKQ 1099
            :.||..|||||||:||.||:|.|::||.::|:..|:|  |..:||..:|:.:|.|.||::|||.|
  Fly  1218 DAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIAFISTDYILPSEMCAMVNVILDAKNQ 1282

Human  1100 STKLCALDGGQEFGSQWQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSS 1164
            |.||..:||...:     ::|:||||.||.:...:...|..|.:||||..||||:|||||:...|
  Fly  1283 SFKLTTIDGIDLY-----KFHAKIDDQIDKANVAMTQGLSGKLMSVLESTLSKLARYDEGSLIGS 1342

Human  1165 ILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVW 1229
            |||||        :|...|.||...|:.|.|.|.|.:|.|:.::::....|:||||..:.::|.|
  Fly  1343 ILSFT--------NVSSSGKDLGQGYVNFFRNNMDQVRGKIADDLWTLHFFEQWYSQQINMLCNW 1399

Human  1230 LTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGL 1294
            |::|:|..||..|:.::..|:||.|.||.||||||..||||.|..|.:|:..||||.:
  Fly  1400 LSERVDHALHYAQVASISHIIKKIYSDFELQGVLEDKLNSKAYQAVAQRMATEEATCA------- 1457

Human  1295 QGITMKDSDEEE 1306
              :||.|:.|:|
  Fly  1458 --LTMPDACEDE 1467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CADPS2	NP_001350318.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78		30/159 (19%)
		C2	366..448	CDD:214577	66/82 (80%)
		PH_CADPS	481..600	CDD:269940	83/125 (66%)
		MUN	801..1257	CDD:461870	229/544 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1286..1308		5/21 (24%)
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	84/126 (67%)
		MUN	904..1427	CDD:461870	229/544 (42%)