DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGAP18 and cv-c

DIOPT Version :9

Sequence 1:	NP_277050.2	Gene:	ARHGAP18 / 93663	HGNCID:	21035	Length:	663	Species:	Homo sapiens
Sequence 2:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster

Alignment Length:	869	Identity:	172/869 - (19%)
Similarity:	303/869 - (34%)	Gaps:	298/869 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    58 KPPFDRSISQDSLDELSMEDYW----------------IELE-------NIKKSSENSQEDQEVV 99
            ||...:...:...:..::.::|                :||.       |::|:..:|:|
  Fly  1447 KPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPPPGLLSLNVEKTESSSKE----- 1506

Human   100 VVKEPDEGELEEEWL--------KEAGLSNLFGESAGDPQESIVFLSTLTRT-------QAAAVQ 149
              ..||..|.:...:        |..|:.| .|.|.|:..:|    ..|.|:       ||.|:.
  Fly  1507 --SSPDRFEEDGAGITLVTPGCSKAGGIPN-DGSSLGEGSDS----GRLRRSGSERIKDQAKALL 1564

Human   150 KRVETVSQTLRKKNKQYQI----PDVRDI--FAQQ------------------------------ 178
            :|||::....||:..:..:    |.|.|:  |.|:
  Fly  1565 RRVESIKSRRRKRQNRENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPPSPSALSPMHTFPKAPF 1629

Human   179 ------------------RESKETAPGGTESQSLRTNENKY---------QGRDDEASNLV---- 212
                              |.|.:..|  |..:|:||:...:         :|:.|::|:..
  Fly  1630 FGNDLKVPSHSDNFLSPNRSSPKRTP--TTPRSMRTSPLHFFSSPMSQLKEGKSDDSSSYYSDSQ 1692

Human   213 ---------------------------------------GEEKLIPPEETPAPET---------D 229
                                                   |.:.||....:...|.         .
  Fly  1693 ESSTGGKLSLRKPSKARRFLQRTGKVDDIGAHSDSECHQGRKLLIKDANSNTTEVKVKKLTRGGS 1757

Human   230 INL-----------EVSFAEQALNQKESSKEKI---QKSKGDDATLP-----SFRLP-------- 267
            :||           ..||..::.::||:..::.   ..:.|.....|     ||::.
  Fly  1758 LNLGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEERPNMIFR 1822

Human   268 ----------KDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVL------GIELKQQKAV-KIK 315
                      ::..|......::...::.:..|||:.||...:..      |...:..|.: |||
  Fly  1823 KCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIK 1887

Human   316 T---KDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLC 377
            .   ||..:|.|||..:|::.     |..:||..:.....::...|:..|:.|..|...||..|.
  Fly  1888 MPDYKDKKVFGVPLLMILQRS-----GQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLR 1947

Human   378 QELEAKFYEGTFNWESV----KQHDAASLLKLFIRELPQPLLSVEYLKAFQAV-QNLPTKKQQLQ 437
            :::|..  :.|.....|    :.:|.|.:||.:.||||:.||:.:..:.|.|: |:||. :.:|.
  Fly  1948 EQIEVT--DSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPA-EVRLD 2009

Human   438 ALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHA----------- 491
            |:...|:||||.||:.|..|||||..|..|.::|:||..|:.:.:|.::|  |:
  Fly  2010 AVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIF--HSSISTGSASVSA 2072

Human   492 ------LGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKK 550
                  .|....:.:|...|..:...:..:|::.|.::|..|   .::.|.|....::.|....:
  Fly  2073 SPRRKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAK---EKLSKCNFSYMEESKPLPLE 2134

Human   551 LL---------KKMAYD------REKYEK-----QDKSTNDADVPQGVIRVQAPH---LSKVSMA 592
            .|         :...|:      :|..||     ...|.||:.|.....:|...|   |.:.|..
  Fly  2135 ALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTE 2199

Human   593 IQLTEELKASDVLARFLSQESG------VAQTLKK----GEVFLYEIGGNIGERCLDDDTYMKDL 647
            |    |....:||...:.|.:.      ..||:||    .|::.|.:.|.:........::..||
  Fly  2200 I----EGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALDGQLTTDFCVLRSWQTDL 2260

Human   648 YQLNPNAEWVI--------KSKPL 663
                |....||        |:|||
  Fly  2261 ----PRGACVIVETSIDHAKAKPL 2280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP18	NP_277050.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..227		13/99 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..277		7/59 (12%)
		RhoGAP_ARHGAP18	321..534	CDD:239856	64/234 (27%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	65/235 (28%)
		SRPBCC	2148..2343	CDD:301327	33/141 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810