DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KL and CG9701

DIOPT Version :9

Sequence 1:	NP_004786.2	Gene:	KL / 9365	HGNCID:	6344	Length:	1012	Species:	Homo sapiens
Sequence 2:	NP_648918.1	Gene:	CG9701 / 39872	FlyBaseID:	FBgn0036659	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	182/506 - (35%)
Similarity:	259/506 - (51%)	Gaps:	74/506 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    61 FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTH-HPLAPPGDSRNASLPLGAPSPLQPATGDV 124
            ||:.|||.|||::||.||||....||.||||..|| ||                ...:..:.|||
  Fly    26 FPNDFLWGVGSSSYQIEGGWNADDKGESIWDFLTHTHP----------------EKIVDRSNGDV 74

Human   125 ASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVV 189
            ::|||:...||.:.::||.|..||||:||.|::|.|.....:..|::||..|::.|....:.|:|
  Fly    75 SADSYHQWKRDVQMVKELHVGTYRFSLSWPRIMPGGYMNHVSTAGIKYYSNLIDELLRYNITPMV 139

Human   190 TLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLA 254
            |:|||:|||:||: .|||.|..:...|:|||.|....:|.:||.|.|::.|:.|..|||....:|
  Fly   140 TIYHWELPQKLQE-LGGWTNPEIIPLFKDYARLVLEMYGDRVKIWTTVNEPWHVCEHGYGVDYMA 203

Human   255 PGIR--GSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKEC- 316
            |...  |.|  .||..||||.|||:|.|:|...|:|.|||::.|.|.:.|..||.......:|.
  Fly   204 PSYNYPGIP--AYLCGHNLLKAHAEVVHMYRELFQPRQGGRMGITLDTSWPEPRDPNSAEDREAS 266

Human   317 QKSLDFVLGWFAKPVFI-DGDYPESM---KNNLS--------SILPDFTESEKKFIKGTADFFAL 369
            ::::.|.:|||..|:|. .|:||:.|   ..|||        |.||:||..|...|:||:|||.:
  Fly   267 ERAMQFYVGWFGHPIFSKHGNYPKVMIERIRNLSKEQGFGARSRLPEFTTEEIHRIRGTSDFFGI 331

Human   370 CFGPTLSFQLLDPHMKFRQLESPN------------------------------LRQLLSWIDLE 404
             ...|.:....:.|....:...|:                              :..||.||..|
  Fly   332 -NSYTSNLVTSNGHNNTGKFPVPSFNHDMGVVESQEGVDWPGSGSVWLKVYPKGMYNLLMWIHRE 395

Human   405 FNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRG 469
            :|.|:|.:.|||  ||.....:|...:.|...::...|.|:: ||.::.||.||||||.:||..|
  Fly   396 YNAPEIIVTENG--VSDRGGLEDYARVDYYNLYLSAVLDAME-DGANISGYIAWSLMDSYEWKAG 457

Human   470 YSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNGF-----PPLPENQPL 515
            :|.:.||::|||.|..:...||.||..:.:|.:.|..     |.|.|.|.|
  Fly   458 FSEKFGLYHVDFNSPQRTRTPKISARVFAQLCKTNTIDWSYRPKLDEEQQL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KL	NP_004786.2	Glycosyl hydrolase-1 1	57..506		177/490 (36%)
		Glyco_hydro_1	58..506	CDD:304882	177/490 (36%)
		Glycosyl hydrolase-1 2	515..953		1/1 (100%)
		Glyco_hydro_1	517..953	CDD:304882
CG9701	NP_648918.1	Glyco_hydro_1	22..492	CDD:304882	176/488 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156851
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257823at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100193
Panther	1	1.100	-	-	O	PTHR10353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3725
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.780