Protein Alignment LONP1 and PIM1

DIOPT Version :10

• Sequence 1: NP_004784.2
• Gene: LONP1 / 9361
• HGNCID: 9479
• Length: 959
• Species: Homo sapiens
• Sequence 2: NP_009531.1
• Gene: PIM1 / 852259
• SGDID: S000000118
• Length: 1133
• Species: Saccharomyces cerevisiae
• Alignment Length: 987
• Identity: 417/987 - (42%)
• Similarity: 602/987 - (60%)
• Gaps: 124/987 - (12%)

Human    70 EASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPV 134
            |||.....:.|||..:|...::.|.|      .:.:.|      |..:|:|:|.:..:.|.|.|:
Yeast   140 EASKNSRSSASGGGQSSSSRSDSGDG------SSKQKP------PKDVPEVYPQMLALPIARRPL 192

Human   135 FPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQD 199
            ||.|.|.:.:.::::::.::..:...|||:|.|:.::...::||:...:::|..|..|||.....
Yeast   193 FPGFYKAVVISDERVMKAIKEMLDRQQPYIGAFMLKNSEEDTDVITDKNDVYDVGVLAQITSAFP 257

Human   200 LGDK------LRMIVMGHRRVHI----------------SRQLEVE---------PEEPEAENKH 233
            ..|:      :..::..|||:.|                ::..:.|         ||:.|:.:..
Yeast   258 SKDEKTGTETMTALLYPHRRIKIDELFPPNEEKEKSKEQAKDTDTETTVVEDANNPEDQESTSPA 322

Human   234 KPRRKSKRGKKEAEDELSARHPAELAMEPTPEL----------PAEVL------MVEVENVVHED 282
            .|:.:....::..:.||......|...|.:.||          |.|.|      :|.|.|:..|.
Yeast   323 TPKLEDIVVERIPDSELQHHKRVEATEEESEELDDIQEGEDINPTEFLKNYNVSLVNVLNLEDEP 387

Human   283 F-QVTEEVKALTAEIVKTIRDIIALNPLYRESV----LQMMQAGQRVVDNPIYLSDMGAALTGAE 342
            | :.:..:.|||:||:|..::|..||.::||.:    ..:..|...:.:.|..|:|..||::..|
Yeast   388 FDRKSPVINALTSEILKVFKEISQLNTMFREQIATFSASIQSATTNIFEEPARLADFAAAVSAGE 452

Human   343 SHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKEL 407
            ..||||:|...||..||.|:|.:||||...::||.::.::||.||::..|:|.|.||||.||:||
Yeast   453 EDELQDILSSLNIEHRLEKSLLVLKKELMNAELQNKISKDVETKIQKRQREYYLMEQLKGIKREL 517

Human   408 GLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGK 472
            |:: |.:|.:.:.::||:|.|.:|..|..:.|:|::||..|:...|||.|.||||||||||||||
Yeast   518 GID-DGRDKLIDTYKERIKSLKLPDSVQKIFDDEITKLSTLETSMSEFGVIRNYLDWLTSIPWGK 581

Human   473 YSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIA 537
            :|.|...:.||:.:|:||||||.|||.||||||||.:|.|...|||:||.||||||||||.:|||
Yeast   582 HSKEQYSIPRAKKILDEDHYGMVDVKDRILEFIAVGKLLGKVDGKIICFVGPPGVGKTSIGKSIA 646

Human   538 RALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGR-GYQG 601
            |||||::|||||||||||||||||||||:||:||:::|.|||.:|:||||||||:||||. |..|
Yeast   647 RALNRKFFRFSVGGMTDVAEIKGHRRTYIGALPGRVVQALKKCQTQNPLILIDEIDKIGHGGIHG 711

Human   602 DPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEK 666
            |||:||||:||||||.:|||:|||:|:|||||||:||||..:|||.||.||||:|.::||||::|
Yeast   712 DPSAALLEVLDPEQNNSFLDNYLDIPIDLSKVLFVCTANSLETIPRPLLDRMEVIELTGYVAEDK 776

Human   667 LAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIV--- 728
            :.|||:||||.|:...||:.|...::.|.:|.|:|.||||||||||:|.:||:.||:|.::|
Yeast   777 VKIAEQYLVPSAKKSAGLENSHVDMTEDAITALMKYYCRESGVRNLKKHIEKIYRKAALQVVKKL 841

Human   729 ---------------------------------------------------SGEAESVEVTPENL 742
                                                               :.|..:|.::.:||
Yeast   842 SIEDSPTSSADSKPKESVSSEEKAENNAKSSSEKTKDNNSEKTSDDIEALKTSEKINVSISQKNL 906

Human   743 QDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLG 807
            :|:||.||:|.:|:|:.||||||||||||.|||.:|:||:.|.:|    ....|..:.|.|||||
Yeast   907 KDYVGPPVYTTDRLYETTPPGVVMGLAWTNMGGCSLYVESVLEQP----LHNCKHPTFERTGQLG 967

Human   808 EVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRP 872
            :|||||:|:||:||:.:|.|..|.|.:...:.||||.|||||||||||||.|:.|:.||||:.:.
Yeast   968 DVMKESSRLAYSFAKMYLAQKFPENRFFEKASIHLHCPEGATPKDGPSAGVTMATSFLSLALNKS 1032

Human   873 VRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVE 937
            :...:|||||::||||:|.:||::||.:||||:|...|:.|.:|..|:.:|...:.||||....:
Yeast  1033 IDPTVAMTGELTLTGKVLRIGGLREKAVAAKRSGAKTIIFPKDNLNDWEELPDNVKEGLEPLAAD 1097

Human   938 HYREIFDIAFPD 949
            .|.:||...|.|
Yeast  1098 WYNDIFQKLFKD 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LONP1	NP_004784.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..102		6/24 (25%)
		lon	125..947	CDD:273258	401/928 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..257		7/47 (15%)
PIM1	NP_009531.1	lon	183..1107	CDD:273258	401/928 (43%)