Protein Alignment LONP1 and lonp1

DIOPT Version :10

• Sequence 1: NP_004784.2
• Gene: LONP1 / 9361
• HGNCID: 9479
• Length: 959
• Species: Homo sapiens
• Sequence 2: XP_691712.4
• Gene: lonp1 / 563257
• ZFINID: ZDB-GENE-030131-4006
• Length: 966
• Species: Danio rerio
• Alignment Length: 972
• Identity: 740/972 - (76%)
• Similarity: 820/972 - (84%)
• Gaps: 35/972 - (3%)

Human     1 MAASTGYVRLW----GAARCWVLRR------PMLAAAGGRVPTAAGA--WLLRGQRTCDASPPWA 53
            |||   |:|:|    |:....::|.      |.|.....|..:...:  .|...:|:...:..|:
Zfish     1 MAA---YMRVWRSSSGSGSSAIIRAGINALFPRLTLGSSRSYSIIRSRDCLSAARRSASLTDRWS 62

Human    54 LWGRGPAIGGQWRGFWEASSRGGGAFSG--GEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMT 116
              |.|.|..|...|..:..|..|...||  |||.:|....  |.|.||.......|.::|||||.
Zfish    63 --GGGSAGSGGLTGGCQTRSVFGNRSSGFSGEDGAESSGT--ADGDGGDEAPDSPPQMSALTPML 123

Human   117 IPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVES 181
            :|:|||::||||:.|||||||||||||||||:|:|||||||||||||.|||||||||||||||||
Zfish   124 VPEVFPNVPLIAVNRNPVFPRFIKIIEVKNKQLMELLRRKVRLAQPYAGVFLKRDDSNESDVVES 188

Human   182 LDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEP-----EAENKHKPRRKSKR 241
            ||.:||||||.|||||||||||||||||||||:.|::.|.||||||     |||.:...|||.||
Zfish   189 LDAVYHTGTFVQIHEMQDLGDKLRMIVMGHRRIRINKALSVEPEEPEPMEAEAEEQKSSRRKQKR 253

Human   242 GKKEAED-----ELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIR 301
            .::|.|.     |.:.|. |:|.:|..|  |..||||||:||.||:|||||||||||||||||||
Zfish   254 SRREPEPLADLMEQTVRE-ADLRVEALP--PPSVLMVEVDNVAHEEFQVTEEVKALTAEIVKTIR 315

Human   302 DIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLL 366
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   316 DIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLL 380

Human   367 KKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVP 431
            |||:|||||||||||||||||||||||||||||||||||||||||:|||||||||||||::..||
Zfish   381 KKEYELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKEDKDAIEEKFRERLRDRTVP 445

Human   432 KHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMED 496
            :|:|||::|||:||||||||||||||||||||||||:|||..|.|||:|.||:.|||||||||:|
Zfish   446 QHIMDVINEELNKLGLLDNHSSEFNVTRNYLDWLTSMPWGTNSEENLELRRAKEVLEEDHYGMDD 510

Human   497 VKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGH 561
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   511 VKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGH 575

Human   562 RRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDV 626
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Zfish   576 RRTYVGAMPGKIIQCLKKTKTENPLVLIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDV 640

Human   627 PVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKL 691
            ||||||||||||||:||||||||||||||||||||||||||||||:|||||.|.||||||.|.|:
Zfish   641 PVDLSKVLFICTANITDTIPEPLRDRMEMINVSGYVAQEKLAIAEKYLVPQLRTLCGLDEQKVKI 705

Human   692 SSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERM 756
            :.:.|.|||:||||||||||||||||||.||.|::|||||..:|:||..||||:||||:|||:||
Zfish   706 NPEALNLLIRQYCRESGVRNLQKQVEKVFRKVAFRIVSGEETAVDVTSNNLQDYVGKPLFTVDRM 770

Human   757 YDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAK-GDKDGSLEVTGQLGEVMKESARIAYTF 820
            |||||||||||||||||||||||:|||||||:|...| |.||||||||||||:||||||:|||||
Zfish   771 YDVTPPGVVMGLAWTAMGGSTLFIETSLRRPRDPPGKDGPKDGSLEVTGQLGDVMKESAKIAYTF 835

Human   821 ARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSL 885
            ||:|||:..|.|::||:|||||||||||||||||||||||||||||||....:|||:|||||:||
Zfish   836 ARSFLMKEQPDNEFLVSSHIHLHVPEGATPKDGPSAGCTIVTALLSLATNTALRQNVAMTGELSL 900

Human   886 TGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAF 947
            |||||||||||||||||||||||||:|||||:|||.||..:|||||||||||:|.||:::.|
Zfish   901 TGKILPVGGIKEKTIAAKRAGVTCIILPAENRKDFSDLPEYITEGLEVHFVENYSEIYNLVF 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LONP1	NP_004784.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..102		10/26 (38%)
		lon	125..947	CDD:273258	698/832 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..257		19/48 (40%)
lonp1	XP_691712.4	lon	132..962	CDD:273258	698/832 (84%)