DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LONP1 and lon1

DIOPT Version :9

Sequence 1:	NP_004784.2	Gene:	LONP1 / 9361	HGNCID:	9479	Length:	959	Species:	Homo sapiens
Sequence 2:	NP_593035.1	Gene:	lon1 / 2541875	PomBaseID:	SPAC22F3.06c	Length:	1067	Species:	Schizosaccharomyces pombe

Alignment Length:	908	Identity:	422/908 - (46%)
Similarity:	594/908 - (65%)	Gaps:	87/908 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   116 TIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVE 180
            ::|||:|.|..:.|.|.|:||.|.|.|..||..:.|.::..::..|||:|.||.:|::.::||:.
pombe   154 SVPDVYPQLLALPIARRPLFPGFYKAIVTKNPSVSEAIKELIKKRQPYIGAFLLKDENTDTDVIT 218

Human   181 SLDEIYHTGTFAQIHEM--QDLGDK--LRMIVMGHRRVHISRQLEVEPEEPEAEN---------- 231
            ::|::|..|.||||..:  ...|.:  |..::..|||:.|:   |:.|.:.:|::
pombe   219 NIDQVYPVGVFAQITSIFPAKSGSEPALTAVLYPHRRIRIT---ELIPPKEDADSAASSDAAELE 280

Human   232 -----------KHKPRRKSKRGKKEAEDELSARHPAELAMEPTPEL--PAEVLMVEVENVVHEDF 283
                       :.|...|...||:|.|.|          :|.||.:  ..:|.:|.||||.:|.|
pombe   281 TDKSSNLSSNGEVKSDLKQDNGKEEPEKE----------VESTPSILQNFKVSLVNVENVPNEPF 335

Human   284 QVTEEV-KALTAEIVKTIRDIIALNPLYRESV--LQMMQAGQRVVDNPIYLSDMGAALTGAESHE 345
            :..:.| ||:|:||:...:||..::||:||.:  ..:.|....|.|.|..|:|..||::.|:..|
pombe   336 KRQDPVIKAVTSEIMNVFKDIANVSPLFREQIANFSISQTSGNVFDEPAKLADFAAAVSAADHRE 400

Human   346 LQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLE 410
            ||:|||.|||..||.|||.:||||...::||.::.:|:|:||.|.|::|||.||||.||:|||.|
pombe   401 LQEVLEATNIGDRLQKALYVLKKELLNAQLQHKINKEIEQKITQRHKEYLLTEQLKQIKRELGQE 465

Human   411 KDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSN 475
            .|.|:|:..:|::|.:.|.:|.||..|.::||||...|:..::|||:|||||||:|.:||||.|.
pombe   466 LDSKEALVTEFKKRTESLSMPDHVKKVFNDELSKFQHLEPMAAEFNITRNYLDWITQLPWGKRSV 530

Human   476 ENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARAL 540
            ||.||..|:.||:.||||::|||.|:||.:||.:|||:.||||:|..|||||||||:.:|||.||
pombe   531 ENFDLDHAKEVLDRDHYGLKDVKDRVLELVAVGKLRGTMQGKIMCLVGPPGVGKTSVGKSIASAL 595

Human   541 NREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSS 605
            |||:|||||||:|||||||||||||:|||||||:|.|||.:||||||||||:||:|:.:||||:|
pombe   596 NREFFRFSVGGLTDVAEIKGHRRTYIGAMPGKIVQALKKVQTENPLILIDEIDKVGKSHQGDPAS 660

Human   606 ALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIA 670
            |||||||.|||:.|||:|:|:|:|:|.|||:||||..||||.||.||||:|.:||||:.||:.||
pombe   661 ALLELLDSEQNSAFLDYYMDIPLDVSSVLFVCTANTIDTIPPPLLDRMEVIELSGYVSAEKVNIA 725

Human   671 ERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIV------- 728
            :.||:|||:|.|||.::...:|.|.:..||..|..|||||||:|.:||:.||:::.||
pombe   726 KGYLIPQAKAACGLKDANVNISDDAIKGLISYYAHESGVRNLKKSIEKIFRKTSFSIVKEIDDEL 790

Human   729 ---------SG--------------EAESV----------EVTPENLQDFVGKPVFTVERMYDVT 760
                     ||              ||.||          |:..::|..::|.|::|.:|:||.|
pombe   791 NSKEKSTGKSGKKTSPQSSEDAANKEASSVPLKVPDKVNIEIEEKDLTKYLGPPIYTSQRLYDTT 855

Human   761 PPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFL 825
            ||||||||.||.|||.:::|||.::    .....:...|||.|||||:|||||:.|:|:|:::||
pombe   856 PPGVVMGLGWTPMGGVSMYVETIVK----NILSSNSTPSLERTGQLGDVMKESSEISYSFSKSFL 916

Human   826 MQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKIL 890
            .:|.|.|.:...:.:|:|.|||:..|||||||.|:.|:|||||:..||....|||||::||||||
pombe   917 SKHFPNNKFFEHARLHMHCPEGSISKDGPSAGITMATSLLSLALDTPVPATTAMTGELTLTGKIL 981

Human   891 PVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAE 953
            .:||::|||:|||.:|:..|:.|..|..|:..|..::.|||....|..|.::|...|.:..||
pombe   982 RIGGLREKTVAAKLSGMKEILFPKSNLADWEQLPDYVKEGLTGVPVAWYDDVFKRVFSNIDAE 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LONP1	NP_004784.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..102
		LON	123..200	CDD:197740	28/78 (36%)
		lon	125..947	CDD:273258	414/891 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..257		10/59 (17%)
		P-loop_NTPase	489..>540	CDD:304359	32/50 (64%)
		AAA	519..661	CDD:278434	104/141 (74%)
		ChlI	737..948	CDD:304493	97/210 (46%)
lon1	NP_593035.1	LON	161..>217	CDD:197740	20/55 (36%)
		lon	163..1038	CDD:273258	414/891 (46%)
		AAA	574..716	CDD:278434	104/141 (74%)
		ChlI	832..1035	CDD:304493	96/206 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	227	1.000	Domainoid score	I582
eggNOG	1	0.900	-	-		E1_COG0466
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3521
Inparanoid	1	1.050	787	1.000	Inparanoid score	I87
OMA	1	1.010	-	-		QHG55281
OrthoFinder	1	1.000	-	-		FOG0002884
OrthoInspector	1	1.000	-	-		oto147001
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	1	1.100	-	-	LDO	PTHR43718
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830