DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A6 and CG7333

DIOPT Version :9

Sequence 1:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens
Sequence 2:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	134/557 - (24%)
Similarity:	239/557 - (42%)	Gaps:	32/557 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN-LSKNGGLE 64
            |.|:.:|.:.|..||||.:.:.|.....:|.:.|...|......|.|.|. .||.| ||..|...
  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCF-HADLNGLSVEGIRS 64

Human    65 VWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCS 129
            |:    ......||    :|..|:  :|||   |..:|......||::..:...:|.||...||.
  Fly    65 VY----ENISASSC----TPLLGV--VNGT---GVVSTNRKCRNWIFNRESGYESITTELKWVCD 116

Human   130 HRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLL 194
            ......:.||.:.:|.::|.::||||:|::||...|::..|..|......:|....|.:...|.:
  Fly   117 KSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSRFM 181

Human   195 SGMALAGISLNCMTLNVEWMPIHTRAC-VGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPF 258
            ||::...:......|..|::...:|.. :..::...|..|.......|..:.:||....|.|.|.
  Fly   182 SGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWLASLPA 246

Human   259 FAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKEL---TMG 320
            ....||.:...|||:|..:..:.|..:..|::||:.|.:..|.:... |.::...::||   .:.
  Fly   247 LGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFD-EFVKYYRERELQDYKLN 310

Human   321 KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVG 385
            ..:.:.:.:...|.||...|.|.:.....:.:...:..:::|.|.|.:.:......|.|||.:..
  Fly   311 SHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFTSIVYLPAGVAI 375

Human   386 FLVINSLGRRPAQMAALLLAGICILLNGVI-----PQDQSIVRTSLAVLGKGCLAASFNCIFLYT 445
            .|:.|.:||:.....||.:.|:.....|.:     |.:.:::...:..||:.....|::....|.
  Fly   376 LLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGATVSYDAEIQYA 440

Human   446 GELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQ 510
            .|:.||.:|...:.....:....|.::..|...|:.|..:|......:....:.:.:.|||||.:
  Fly   441 AEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFISCLMFFGAGLCLTLPETLNK 505

Human   511 PLPDTVQDLESRWAPTQKEAGIY----PRKGKQTRQQ 543
            .||:|:.|.| ::|  ..|:.:|    .||.|..|.:
  Fly   506 KLPETLADGE-KFA--LNESFLYFPCFSRKEKNVRTE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	121/513 (24%)
		MFS	135..505	CDD:119392	79/378 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563		6/23 (26%)
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	121/513 (24%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	78/373 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950