DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A6 and CarT

DIOPT Version :9

Sequence 1:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens
Sequence 2:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	152/543 - (27%)
Similarity:	257/543 - (47%)	Gaps:	39/543 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     4 NDLLQQVGGVGRFQQIQVTLVVLPLLL---MASHNTLQNFTAAIPTHH-CRPP--ADANLSKNGG 62
            :|||..:|..|::|::.|..:.||..:   ..:.|.|  |.|..|..: ||.|  .|..|.:...
  Fly    37 DDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQL--FMADTPDDYWCRIPELLDLPLEQRKS 99

Human    63 LEVWLPRDRQGQP---ESCLRFTSPQWGLPFLNGTEANGTGATEP--------CTDGWIYDNSTF 116
            |.:  |::.....   ..|..: ...| ...|...|.:.....||        |..||.|:.|..
  Fly   100 LSI--PKELDNDELVYSKCYTY-GVNW-TQLLESGEEDDLTTMEPNASWPLIKCPQGWEYNTSVV 160

Human   117 PSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY---LQTAVSGT- 177
            .|:||.::||||.......:..:....|..:|..:||.|.||.|||    |:|   |.|.::|:
  Fly   161 WSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRR----LSYFVCLATLLAGSL 221

Human   178 CAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAY 242
            ..:.:.:|..:...|::.|:.:..:......:::|.:..:.|:.|..:....|:.|..||:||.|
  Fly   222 MTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTY 286

Human   243 AVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGA---KL 304
            ....|..|..:.|.||:|:|:|.:...||.||....|||:..|:.|:|:|::||:....|   ||
  Fly   287 LERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKL 351

Human   305 SMEVLRASLQKELTMGKGQASA--MELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSI 367
            ..::.|..|:|:   .|..|:.  .:|.|.|.:|...:.:::.|||....|.||.......|.:.
  Fly   352 EAQIRRDKLKKQ---KKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQ 413

Human   368 YLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKG 432
            |:...:...|:||:.|..:..:::.|||.....:::|.|:..::..::|.|.......|.::.|.
  Fly   414 YVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKA 478

Human   433 CLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAA 497
            .|:|||..|:.:.||||||.:|..|:|..|.:..:|.|..|.::...:....:||.|.|.:.:..
  Fly   479 LLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLG 543

Human   498 SAVTVLLPETLGQPLPDTVQDLE 520
            ....:.|||||...||.|:::.|
  Fly   544 GMTGLRLPETLHHRLPQTIEEGE 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	147/529 (28%)
		MFS	135..505	CDD:119392	104/378 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563
CarT	NP_610052.1	2A0119	44..561	CDD:273328	147/529 (28%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	104/375 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020