Protein Alignment LHX2 and esn

DIOPT Version :9

• Sequence 1: NP_004780.3
• Gene: LHX2 / 9355
• HGNCID: 6594
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Alignment Length: 464
• Identity: 100/464 - (21%)
• Similarity: 146/464 - (31%)
• Gaps: 130/464 - (28%)

Human     2 LFHSLSGPE-----VHGVIDEMDRRAK-SEAPAISSAIDRGDTETTMPSISSDRAALCAGC---- 56
            |.|.|...:     .|.:.||..:..: ..|.....|:.||    .:..:|.:|.  |.||
  Fly   542 LLHQLPPQDNEVRYCHSLSDEERKELRIFSAQRKREALGRG----AVRLLSDERP--CKGCEEPL 600

Human    57 -GGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHL 120
             ||.|......|.....||..|..|..|| .|..:|..|.:||::||.. ::......||:.|.
  Fly   601 SGGDIVVFAQRLGAQLCWHPGCFVCSVCK-ELLVDLIYFQRDGNLYCGR-HHAETQKPRCSACD- 662

Human   121 GISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALL------------ 173
            .|..|:....|....:|:..|.|..|...| .|..:.|::...||...|:.:.
  Fly   663 EIIFSDECTEAEGRTWHMKHFACQECEHQL-GGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIG 726

Human   174 --QGEYP---AHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTV------QKGRPRK 227
              ||:..   .|::..|...:......:.           ||.|:....||:      .||.|..
  Fly   727 VDQGQMSHDGQHWHATDQCFSCCTCRCSL-----------LGRPFLPRRGTIYCSIACSKGEPPT 780

Human   228 RKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPD 292
            ......|..|...:.|.:                |||..|..|...:..:....|::   :.:|.
  Fly   781 PSDTSSGPQLRPTHRAST----------------SSQIAKSPRRGGERERDPGRKAH---HGHPK 826

Human   293 AKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGV------------------------ 333
            |         ||....:|:          |:...|.|..||
  Fly   827 A---------TGSAGDLLE----------RQERQRMEAAGVADLLLGGGVPGMPRPAHPPPIDLT 872

Human   334 ------------DKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVP 386
                        |||.....||.|.|.|...||.|..|.|.......:|.||:...:|.....:.
  Fly   873 ELGISLDNICAGDKSIFGDTQTLTNSMPDMLLSKADDSHSYQSIDKINLNSPSNSDLTQSTQELA 937

Human   387 GNLE-GHEP 394
            ..|| .:||
  Fly   938 NELELDNEP 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	22/67 (33%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	15/57 (26%)
		COG5576	<247..378	CDD:227863	32/166 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..270		4/19 (21%)
		Homeobox	270..323	CDD:395001	7/52 (13%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		1/15 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	328..374		18/81 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..406		4/9 (44%)
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	10/49 (20%)
		LIM1_Prickle	593..651	CDD:188799	20/59 (34%)
		LIM2_Prickle	656..711	CDD:188802	15/56 (27%)
		LIM3_Prickle	716..774	CDD:188804	9/68 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910