DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX2 and HGTX

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	197	Identity:	53/197 - (26%)
Similarity:	77/197 - (39%)	Gaps:	37/197 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   198 SAGLGA-AGANPLGLPYYN----GVGTVQ-----KGRPRKRKSP---------GPG-----ADLA 238
            ||||.| .||   |:|.::    ..|..|     :|.|.|..:.         .||     |:..
  Fly   375 SAGLSALTGA---GIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPGLQGLVANPI 436

Human   239 AYNAALSCNENDAEHLDRDQPYPSSQ---KTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLA 300
            |:...|| |...|......|.:||:.   |.|..|.:|...|:..::..|.........:..:||
  Fly   437 AWRERLS-NTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLA 500

Human   301 QKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASEL---SNASLSPSS 362
            ...|:::..::|||||.|.|:|:....:..|...|..|..   |...|..||.   .|.||....
  Fly   501 YALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDDMG---GDNDGDCSETMDSDNESLDMGE 562

Human   363 TP 364
            :|
  Fly   563 SP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	33/124 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		6/22 (27%)
		Homeobox	270..323	CDD:395001	14/52 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	8/15 (53%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	14/53 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910