DRSC/TRiP Functional Genomics Resources

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Protein Alignment LHX2 and pk

DIOPT Version :9

Sequence 1:NP_004780.3 Gene:LHX2 / 9355 HGNCID:6594 Length:406 Species:Homo sapiens
Sequence 2:NP_724538.1 Gene:pk / 45343 FlyBaseID:FBgn0003090 Length:1299 Species:Drosophila melanogaster


Alignment Length:515 Identity:112/515 - (21%)
Similarity:168/515 - (32%) Gaps:155/515 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    12 HGVIDEMDRRAKSEAPAISS-----AIDRGDTETTMPSISSDRAALCAGCG-----GKISDRYYL 66
            |.:.||    .:.|....|:     |:.||:....|      .|..|.||.     |.|:.....
  Fly   588 HSLTDE----ERKELRLFSTQRKRDALGRGNVRQLM------SARPCDGCDDLISTGDIAVFATR 642

Human    67 LAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRA 131
            |..:..||..|..|..|: .|..:|..|.:||.:||...:..... .||:.|...|.|.|.. .|
  Fly   643 LGPNASWHPACFACSVCR-ELLVDLIYFHRDGRMYCGRHHAETLK-PRCSACDEIILADECT-EA 704

Human   132 RDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALL--------------QGEYPAHFN 182
            ....:|:|.|.|..|:|.| .|..:.|::...||...|:|:.              ||:......
  Fly   705 EGRAWHMNHFACHECDKQL-GGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQ 768

Human   183 HADVAAAAAAAAAAKSAGLGAAGANPLGLPY---------------YNGVGT-VQKGRPRKRKSP 231
            |........:....:.:.||.|.....|..|               .:|.|. .....|.:|..|
  Fly   769 HWHATDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRP 833

Human   232 GPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKH--HQLRTM------------K 282
            .|.|.|.|        ...:.|.....|. |.|:.::.:.:|..  :|:::.            |
  Fly   834 HPQAPLPA--------RIPSSHASSSPPM-SPQQQQQHQATFNQAMYQMQSQQMEAAGGLVDQSK 889

Human   283 SYFAINHNPDA---KDLKQLAQKTG--LTKRVLQVWFQNARAK--------------FRRNLLRQ 328
            ||.|  .:.||   |||:......|  ||.      |...||.              |:.:.|.:
  Fly   890 SYAA--SDSDAGVVKDLEHGGHMGGGDLTD------FSGGRASSTSQNLSPLNSPGDFQPHFLPK 946

Human   329 ----ENTGV------DKSTDAA----------LQTGTPSGPAS----ELSNASLSPSSTPTTLTD 369
                :..||      ..:.|||          ||......|.:    ||:...::|.:....|:.
  Fly   947 PMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTASMPELAGKLVAPPAHMQHLSQ 1011

Human   370 LTS-------------------------PTLPT--VTSVLTSVPGNLEGHEPHSPSQTTL 402
            |.:                         |.|||  ::...|::|..|.|...||....:|
  Fly  1012 LHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMGSPTHSAGDRSL 1071

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LHX2NP_004780.3 LIM1_Lhx2 43..106 CDD:188853 19/67 (28%)
LIM2_Lhx2_Lhx9 111..169 CDD:188763 18/57 (32%)
COG5576 <247..378 CDD:227863 40/214 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..270 4/19 (21%)
Homeobox 270..323 CDD:395001 18/85 (21%)
Nuclear localization signal. /evidence=ECO:0000255 307..323 4/29 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 328..374 13/94 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 387..406 5/16 (31%)
pkNP_724538.1 PET_Prickle 523..618 CDD:193602 8/33 (24%)
LIM1_Prickle 624..682 CDD:188799 18/58 (31%)
LIM2_Prickle 687..742 CDD:188802 18/56 (32%)
LIM3_Prickle 747..805 CDD:188804 8/57 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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