DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and ct

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster

Alignment Length:	289	Identity:	62/289 - (21%)
Similarity:	94/289 - (32%)	Gaps:	85/289 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   111 SVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALL-- 173
            :..|....|:..:..||....:||..|    ..||..|.....::.|.|       :..||:|
  Fly  1594 NAMRSLHQHMSPTVYEMAALTQDLDTH----DITTKIKEALLANNIGQK-------IFGEAVLGL 1647

Human   174 -QGEY--------PAHFNHADVAAAAAAAAAAKSAGLGAAGANP-----LGLPYYNGVGTVQ--- 221
             ||..        |.|.                   |...|..|     |.|...|.|..:|
  Fly  1648 SQGSVSELLSKPKPWHM-------------------LSIKGREPFIRMQLWLSDANNVERLQLLK 1693

Human   222 ---KGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSS--------QKTKRMRTSFKH 275
               :...::|:|.||...    :.:...:.||........|.|.|        ..:|:.|..|..
  Fly  1694 NERREASKRRRSTGPNQQ----DNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSE 1754

Human   276 HQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAA 340
            .|...::..||::..|:...::.||.:.||..|.:..||.|.|.:.::.:
  Fly  1755 EQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQV--------------- 1804

Human   341 LQTGTPSGPASELSNASLSPSSTPTTLTD 369
                 |.|||.: .|...|..||..|..|
  Fly  1805 -----PHGPAGQ-DNPIPSRESTSATPFD 1827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	12/57 (21%)
		COG5576	<247..378	CDD:227863	31/131 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		5/27 (19%)
		Homeobox	270..323	CDD:395001	15/52 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	22/103 (21%)
		Homeobox	1749..1801	CDD:278475	15/51 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910