DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX2 and toy

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	373	Identity:	86/373 - (23%)
Similarity:	152/373 - (40%)	Gaps:	65/373 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    55 GCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKD-GSIYCKEDYYRRFSVQRCARC 118
            ||..||..|||.....|...:...|.......:..::..:.:: .||:..|...|..|.|.|...
  Fly    76 GCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSD 140

Human   119 HL-GISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGE------ 176
            :: .:|:...|:|                |...........::..||.:|.   :..|:
  Fly   141 NIPSVSSINRVLR----------------NLASQKEQQAQQQNESVYEKLR---MFNGQTGGWAW 186

Human   177 YPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYN 241
            ||::...|.:....||:.....|.|.               |...:...:||:... ..:::..|
  Fly   187 YPSNTTTAHLTLPPAASVVTSPANLS---------------GQADRDDVQKRELQF-SVEVSHTN 235

Human   242 AALSCNENDAEH-----LDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQ 301
            :..|.::.::||     .|........:|.:|.||||.:.|:.:::..|...|.||....::||.
  Fly   236 SHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLAD 300

Human   302 KTGLTKRVLQVWFQNARAKFRR-NLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPS--ST 363
            |.||.:..:||||.|.|||:|| ..:|.:....| :.|.:.:|.|.:.|:...:::|::.|  ||
  Fly   301 KIGLPEARIQVWFSNRRAKWRREEKMRTQRRSAD-TVDGSGRTSTANNPSGTTASSSVATSNNST 364

Human   364 P-----------TTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQT 400
            |           .|.:.|.|.:||..::..|.:.|  |.:..|:.|::
  Fly   365 PGIVNSAINVAERTSSALVSNSLPEASNGPTVLGG--EANTTHTSSES 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	12/51 (24%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	10/58 (17%)
		COG5576	<247..378	CDD:227863	45/149 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		5/24 (21%)
		Homeobox	270..323	CDD:395001	22/52 (42%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		8/15 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		13/58 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		4/14 (29%)
toy	NP_001368990.1	PAX	29..153	CDD:128645	18/76 (24%)
		COG5576	<253..368	CDD:227863	38/115 (33%)
		Homeobox	269..322	CDD:395001	22/52 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910