DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and C15

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_476873.2	Gene:	C15 / 42544	FlyBaseID:	FBgn0004863	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	192	Identity:	44/192 - (22%)
Similarity:	62/192 - (32%)	Gaps:	60/192 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   178 PAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNA 242
            |.|  ||.:|..|.....|.:..:    |..:|.||.|..       |.|||.|
  Fly   180 PLH--HAALAHQAVKDRLAAAFPI----ARRIGHPYQNRT-------PPKRKKP----------- 220

Human   243 ALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTK 307
                                       ||||...|:..::..|.......:.:...||:...:|.
  Fly   221 ---------------------------RTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTD 258

Human   308 RVLQVWFQNARAKFRRNLL------RQENTGVDKSTDA-ALQTG--TPSGPASELSNASLSP 360
            ..::.||||.|.|:||...      ||....:..|..| |:..|  .||.|.......:.:|
  Fly   259 AQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQAEAISKGFAPPSAPLGSQGGVNGAP 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	27/123 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		0/19 (0%)
		Homeobox	270..323	CDD:395001	15/52 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
C15	NP_476873.2	COG5576	<196..315	CDD:227863	37/167 (22%)
C15	NP_476873.2	Homeobox	220..273	CDD:278475	16/90 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910