DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and Poxm

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001036687.1	Gene:	Poxm / 40990	FlyBaseID:	FBgn0003129	Length:	370	Species:	Drosophila melanogaster

Alignment Length:	191	Identity:	37/191 - (19%)
Similarity:	58/191 - (30%)	Gaps:	58/191 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   177 YPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYN 241
            :|.|.:|...|||||:|....:.....|       ..||.:..             |.:..|||:
  Fly   190 HPHHHHHHQSAAAAASAHHVHAHAHAHA-------HLYNSIYQ-------------PYSAAAAYS 234

Human   242 AALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKH-HQLRTMKSYFAINHNPDAKDLKQLAQKTGL 305
            ....|..            ||..:....:.|..| ||||::.:..|..|.|.:..:..:
  Fly   235 MKTPCGS------------PSPPQGAGGQGSVPHPHQLRSVAAAAAAAHWPSSHSVSDI------ 281

Human   306 TKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTT 366
                               |...:...:..|....:..|...|..|.:|...::||....|
  Fly   282 -------------------LAHHQAVALRASCQVGVGVGGMGGMGSTVSPLPMTPSPVAGT 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	20/121 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		2/19 (11%)
		Homeobox	270..323	CDD:395001	9/53 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		0/15 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Poxm	NP_001036687.1	PAX	10..133	CDD:128645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910