DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and Antp

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	228	Identity:	49/228 - (21%)
Similarity:	83/228 - (36%)	Gaps:	52/228 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   147 NKMLTTGDHFGMKDS-LVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLG 210
            |..:|...|.|...: |.|..:....:.:    .|.||.::      ....:.:|:...||.|.|
  Fly   192 NAQMTLPHHMGHPQAQLGYTDVGVPDVTE----VHQNHHNM------GMYQQQSGVPPVGAPPQG 246

Human   211 LPYYNGVGTVQ--KGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYP-------SSQKT 266
            : .:.|.|..|  :|.|.:...|             |.|.|..........||       ..|:.
  Fly   247 M-MHQGQGPPQMHQGHPGQHTPP-------------SQNPNSQSSGMPSPLYPWMRSQFGKCQER 297

Human   267 KRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENT 331
            ||.|.::..:|...::..|..|.....:...::|....||:|.:::||||.|.|:::     ||.
  Fly   298 KRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKK-----ENK 357

Human   332 GVDKSTDAALQTGTPSGPASELSNASLSPSSTP 364
                         |...|.|......::|.::|
  Fly   358 -------------TKGEPGSGGEGDEITPPNSP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	6/22 (27%)
		COG5576	<247..378	CDD:227863	28/125 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		5/26 (19%)
		Homeobox	270..323	CDD:395001	14/52 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	29/137 (21%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	14/52 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910