DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and ftz

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_477498.1	Gene:	ftz / 40834	FlyBaseID:	FBgn0001077	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	391	Identity:	69/391 - (17%)
Similarity:	106/391 - (27%)	Gaps:	172/391 - (43%)

- Green bases have known domain annotations that are detailed below.

Human   149 MLTTG--DHFGMKDSL-VYCRLHFEAL-------------------LQGEYPA--------HFNH 183
            |.||.  .|:...|:: :|...|..:|                   .||.||.        ::|:
  Fly     1 MATTNSQSHYSYADNMNMYNMYHPHSLPPTYYDNSGSNAYYQNTSNYQGYYPQESYSESCYYYNN 65

Human   184 --------------------------ADVAAAAAAAAAAKSAGLGAAGANPL-GLPY-----YNG 216
                                      .|.||:..||...:.:.|.|...||: .|.|     |..
  Fly    66 QEQVTTQTVPPVQPTTPPPKATKRKAEDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTT 130

Human   217 VGTVQKGRPRKRK---SPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQK------------- 265
            |..|:|......|   ||.|..|.............|.::||...|...:||
  Fly   131 VEQVKKAPAVSTKVTASPAPSYDQEYVTVPTPSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTT 195

Human   266 ----------------------------------------------------------TKRMRTS 272
                                                                      :||.|.:
  Fly   196 PTSLPPLEGISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQT 260

Human   273 FKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKST 337
            :..:|...::..|..|.....:....:|....|::|.:::||||.|.|.::          |::.
  Fly   261 YTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKK----------DRTL 315

Human   338 DAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSP--TLPTVTSVLTSVPGNLEGHEPHSPSQT 400
            |:                   ||.......|.:..|  ...|.|:...|||..:..|.     ||
  Fly   316 DS-------------------SPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHH-----QT 356

Human   401 T 401
            |
  Fly   357 T 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	6/22 (27%)
		COG5576	<247..378	CDD:227863	27/203 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		8/90 (9%)
		Homeobox	270..323	CDD:395001	13/52 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		6/47 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		4/15 (27%)
ftz	NP_477498.1	FTZ	1..248	CDD:281812	39/246 (16%)
ftz	NP_477498.1	Homeobox	257..310	CDD:278475	13/52 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910