DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and MICAL-like

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_648621.1	Gene:	MICAL-like / 39475	FlyBaseID:	FBgn0036333	Length:	1010	Species:	Drosophila melanogaster

Alignment Length:	52	Identity:	15/52 - (28%)
Similarity:	28/52 - (53%)	Gaps:	1/52 - (1%)

- Green bases have known domain annotations that are detailed below.

Human   114 RCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYC 165
            :|.:|:|.:..:|.|:..: ..||..|..|..|:.:||.|..:..:.:.:||
  Fly   149 KCQKCNLPVFLAERVLVGK-RAYHRTCLKCARCSSLLTPGSFYETEVNNIYC 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	15/52 (29%)
		COG5576	<247..378	CDD:227863
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270
		Homeobox	270..323	CDD:395001
		Nuclear localization signal. /evidence=ECO:0000255	307..323
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
MICAL-like	NP_648621.1	CH	14..111	CDD:278723
		LIM_like_1	146..207	CDD:188784	15/52 (29%)
		DUF3585	778..933	CDD:288945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910