DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and eyg

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001014582.1	Gene:	eyg / 39419	FlyBaseID:	FBgn0000625	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	237	Identity:	70/237 - (29%)
Similarity:	109/237 - (45%)	Gaps:	46/237 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   184 ADVAAAAAAA------AAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRK-SPGPGADLAAYN 241
            |::..:||:|      .:..||.|.|.||.               |.|..|. |||.|    :::
  Fly   279 ANLPPSAASAVPVSTCGSLSSAHLMAGGAG---------------GTPTNRAISPGSG----SHD 324

Human   242 AALSCNEN---DAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKT 303
            ...|.:||   |:::||.|    ...|.:|.||:|...||..::..|..:|.|.....::|:.:|
  Fly   325 TLESADENRHIDSDYLDDD----DEPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRT 385

Human   304 GLTKRVLQVWFQNARAKFRR----NLLRQENTG------VDKSTDAALQTGTPSGPASELSNASL 358
            .|::..:||||.|.|||:||    |||:::.:.      ..:|.||...:.|||..:|..::|.:
  Fly   386 SLSEARVQVWFSNRRAKWRRHQRMNLLKRQRSSPANPLHSQQSNDAPASSPTPSNHSSASTSAPV 450

Human   359 S---PSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSP 397
            :   |...|..|....||..|..:.:|..:.|...||..|.|
  Fly   451 APVPPPQQPLPLCGDHSPQGPPPSVLLHPLHGPPGGHHHHHP 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	46/146 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		6/19 (32%)
		Homeobox	270..323	CDD:395001	19/52 (37%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		8/15 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		5/11 (45%)
eyg	NP_001014582.1	HTH	120..217	CDD:304362
eyg	NP_001014582.1	Homeobox	352..404	CDD:278475	19/51 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910