DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and Poxn

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001261016.1	Gene:	Poxn / 36741	FlyBaseID:	FBgn0003130	Length:	425	Species:	Drosophila melanogaster

Alignment Length:	234	Identity:	62/234 - (26%)
Similarity:	85/234 - (36%)	Gaps:	44/234 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   187 AAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGA--DLAAYNAALSCNEN 249
            ||||||||||..||.|.:          ||.|......|.....|.|.|  .:|.|....:...|
  Fly   148 AAAAAAAAAAHQAGSGPS----------NGYGGQAPPPPVTVAPPTPAATPSIARYAKPPALMMN 202

Human   250 DAEHLDRDQPYPSSQKTKRMRTSFKH-HQLRTMKSYFAINHNPDAKDLKQLA-QKTGLTKRVLQV 312
            .|..:. .:|.|      :|..|..| |.       ..:|.|....||...| .|..|....|..
  Fly   203 SAGEMP-IKPAP------KMPPSMGHGHS-------HGLNPNVSGLDLSYSALHKHWLWNPSLLY 253

Human   313 WFQ---NARA--------KFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTT 366
            :.|   .|:|        .:....|.........|:.:||...|.|..:.:||    :|.:....
  Fly   254 YTQAHIQAQAAASGGQFLPYAGGYLPHAMAAAAASSTSALGGFTKSESSIDLS----TPGAAGDA 314

Human   367 LTDLTS-PTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTN 404
            |:|..| .:.|...|:..|..||..|..|.:...:||::
  Fly   315 LSDCDSGKSSPAALSLTASGGGNGAGSAPEASPGSTLSH 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	32/144 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		3/19 (16%)
		Homeobox	270..323	CDD:395001	14/65 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		6/18 (33%)
Poxn	NP_001261016.1	HTH	5..133	CDD:304362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910