DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and inv

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster

Alignment Length:	194	Identity:	51/194 - (26%)
Similarity:	72/194 - (37%)	Gaps:	49/194 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   189 AAAAAAAAKSAGLGAAGANPLGLP-------YYNGVGTVQKGRPRKRKSP--------GPGADLA 238
            ||.|.|...|...|.....|:..|       |.:...:.:..|.||.|.|        |.|..:.
  Fly   394 AAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGGGGGVE 458

Human   239 AYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKT 303
            ...||      |...:..|         ||.||:|...||..:|..|..|.....|..:||:.:.
  Fly   459 KGEAA------DGGGVPED---------KRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGEL 508

Human   304 GLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSST-PTT 366
            ||.:..:::||||.|||.:::                  :||.:..|.:|....|...|| |.|
  Fly   509 GLNEAQIKIWFQNKRAKLKKS------------------SGTKNPLALQLMAQGLYNHSTIPLT 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	33/121 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		4/19 (21%)
		Homeobox	270..323	CDD:395001	20/52 (38%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
inv	NP_523699.3	Homeobox	474..527	CDD:278475	20/52 (38%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	8/42 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910