DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and eve

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_523670.2	Gene:	eve / 36039	FlyBaseID:	FBgn0000606	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	196	Identity:	51/196 - (26%)
Similarity:	82/196 - (41%)	Gaps:	35/196 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   221 QKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQL-RTMKSY 284
            |.|:|   ::|.|..     |..||..:|.... .|....|:....:|.||:|...|| |..|.:
  Fly    34 QYGKP---QTPPPSP-----NECLSSPDNSLNG-SRGSEIPADPSVRRYRTAFTRDQLGRLEKEF 89

Human   285 FAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTD----------A 339
            :..|:....:.. :||.:..|.:..::|||||.|.|.:|..:..........:|          |
  Fly    90 YKENYVSRPRRC-ELAAQLNLPESTIKVWFQNRRMKDKRQRIAVAWPYAAVYSDPAFAASILQAA 153

Human   340 ALQTGTPSGP----ASELSNASLSPSSTP---TTLTDLTSPTLPTVTSVLTSVPGNLEGHEPH-S 396
            |...|.|..|    |:..:.|:.:.::.|   |.:..:..|.:||:     .:||: .||..| |
  Fly   154 ANSVGMPYPPYAPAAAAAAAAAAAVATNPMMATGMPPMGMPQMPTM-----QMPGH-SGHAGHPS 212

Human   397 P 397
            |
  Fly   213 P 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	35/148 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		3/19 (16%)
		Homeobox	270..323	CDD:395001	18/53 (34%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		10/62 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		6/12 (50%)
eve	NP_523670.2	Homeobox	74..126	CDD:278475	18/52 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910