DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and cad

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001260641.1	Gene:	cad / 35341	FlyBaseID:	FBgn0000251	Length:	445	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	59/310 - (19%)
Similarity:	102/310 - (32%)	Gaps:	127/310 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   180 HFNHADVAAAAAAAAAAKSAG-------------LGAAGANPLGLPYYNGVGTVQKGRP------ 225
            |.:||..::::|::.::.|.|             :|..||...|     |||....|.|
  Fly   110 HHHHAHASSSSASSGSSSSGGAPGAPQLNETNSSIGVGGAGGGG-----GVGGATDGGPGSAPPN 169

Human   226 ------------------RKRKSPG-------PGADLAAYNAALSCNENDAEHLDRDQPYPSSQK 265
                              .:..|||       |...||.:.:|::.|.|:..:.:..   ||:..
  Fly   170 HQQHIAEGLPSPPITVSGSEISSPGAPTSASSPHHHLAHHLSAVANNNNNNNNNNNS---PSTHN 231

Human   266 TKRMRTSFKHHQLRTMKS---YF--------------AINHNPDAKDL----------------- 296
            ......|..::. ||..|   ||              .::.:|:.:||
  Fly   232 NNNNNNSVSNNN-RTSPSKPPYFDWMKKPAYPAQPQPDLSSSPNLEDLSDLLDASGKTRTKDKYR 295

Human   297 --------------------------KQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDK 335
                                      .:|||...|::|.:::||||.|||.|    :|...|.|.
  Fly   296 VVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKER----KQNKKGSDP 356

Human   336 STDAALQTGTPSGPASEL--SNASLSPS-----STPTTLTDLTSPTLPTV 378
            :   .:..|......|:|  :.|.|.|.     |...::..:.:..:|.:
  Fly   357 N---VMGVGVQHADYSQLLDAKAKLEPGLHLSHSLAHSMNPMAAMNIPAM 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	37/197 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		2/19 (11%)
		Homeobox	270..323	CDD:395001	21/112 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		8/15 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
cad	NP_001260641.1	Homeobox	295..347	CDD:278475	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910