DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and bsh

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_477350.2	Gene:	bsh / 35266	FlyBaseID:	FBgn0000529	Length:	429	Species:	Drosophila melanogaster

Alignment Length:	292	Identity:	64/292 - (21%)
Similarity:	98/292 - (33%)	Gaps:	99/292 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   176 EYPAHFNH-------ADVAAAAAAAAAAKSAGLGAAG--------ANPL-------GLPYYN--- 215
            ::|:..:|       |..:|:|.|.|.:..|..|.||        :.|.       |..:||
  Fly   100 KHPSQHSHPPQSHPPASASASATATARSNQAASGYAGEDYGKSMHSTPRSNHHSRHGTSHYNGDQ 164

Human   216 -----GVGTVQKGR-PRKRKSPGPGADL----AAYNAALSCNENDAEH----------------- 253
                 |.|..|... |..:..|.|...|    .|.|..|..|....:|
  Fly   165 ISQQLGSGAAQHPPVPTTQPQPPPPPPLNGGSGASNGVLYPNAPYTDHGFLQMTLGYLSPSSGTY 229

Human   254 --LDRDQPYPSSQ---------------------------------KTKRMRTSFKHHQLRTMKS 283
              :|   ||..||                                 :.::.||.|...||..::.
  Fly   230 KSVD---PYFLSQASLFGGAPFFGAPGCVPELALGLGMGVNALRHCRRRKARTVFSDPQLSGLEK 291

Human   284 YFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTG--VDKS-TDAALQTGT 345
            .|.........:..:||...||::..::.||||.|.|.::.|.|::|..  ||.| ::...|.|.
  Fly   292 RFEGQRYLSTPERVELATALGLSETQVKTWFQNRRMKHKKQLRRRDNANEPVDFSRSEPGKQPGE 356

Human   346 PSGPASELSNASLSPSSTPTTLTDLTSPTLPT 377
            .:..:.:..:..|:|.|...|      ||.||
  Fly   357 ATSSSGDSKHGKLNPGSVGGT------PTQPT 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	39/186 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		6/71 (8%)
		Homeobox	270..323	CDD:395001	16/52 (31%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		10/48 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
bsh	NP_477350.2	Homeobox	278..330	CDD:278475	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910