DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and Pax

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	149	Identity:	41/149 - (27%)
Similarity:	61/149 - (40%)	Gaps:	26/149 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    53 CAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCAR 117
            ||.|.|.|.|: .:.|:||.||.....|.:|......| ....:||..||:.||:..|: .:|..
  Fly   407 CAYCNGAILDK-CVTALDKTWHTEHFFCAQCGQQFGEE-GFHERDGKPYCRNDYFEMFA-PKCNG 468

Human   118 CHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFE------------ 170
            |:..|  .|..:.|.:..:|.:||.|..|.:....|..|. .:.|.||..|:.
  Fly   469 CNRAI--MENYISALNSQWHPDCFVCRDCRQPFQGGSFFD-HEGLPYCETHYHAKRGSLCAGCSK 530

Human   171 --------ALLQGEYPAHF 181
                    |:.:..:|.||
  Fly   531 PITGRCITAMFKKFHPEHF 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	18/52 (35%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	15/57 (26%)
		COG5576	<247..378	CDD:227863
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270
		Homeobox	270..323	CDD:395001
		Nuclear localization signal. /evidence=ECO:0000255	307..323
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830
		LIM2_Paxillin_like	407..458	CDD:188723	18/52 (35%)
		LIM3_Paxillin_like	466..518	CDD:188724	16/54 (30%)
		LIM4_Paxillin	525..576	CDD:188795	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910