DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX2 and Lim3

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001260559.1	Gene:	Lim3 / 35184	FlyBaseID:	FBgn0002023	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	389	Identity:	115/389 - (29%)
Similarity:	164/389 - (42%)	Gaps:	110/389 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    32 AIDRGD--TETTMPSISSDRA-----ALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLES 89
            |:|:.|  .|..:..||.:||     ..|.||...|.||:.|..:::.||.:||:|.||...|..
  Fly    94 AVDQDDPNPELVLALISRNRALEATIPKCGGCHELILDRFILKVLERTWHAKCLQCSECHGQLND 158

Human    90 ELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGD 154
            :  ||:::|.::||||:::|:.. :|:.|.:||..:::|.||:|.||||.||.|..|::.|.|||
  Fly   159 K--CFARNGQLFCKEDFFKRYGT-KCSACDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGD 220

Human   155 HFG-MKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVG 218
            .|. |:|..:.|:..:|                        .||:.||           |.:|
  Fly   221 EFYLMEDRKLICKRDYE------------------------EAKAKGL-----------YLDG-- 248

Human   219 TVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKS 283
                                              .||.|||      .||.||:....||.|:|:
  Fly   249 ----------------------------------SLDGDQP------NKRPRTTITAKQLETLKT 273

Human   284 YFAINHNP-DAKDLK-QLAQKTGLTKRVLQVWFQNARAKFRR-----------NLLRQENTGVDK 335
              |.|::| .|:.:: ||:|.|||..||:||||||.|||.:|           ...|........
  Fly   274 --AYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKKDAGRTRWSQYFRSMKGNCSP 336

Human   336 STDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQ 399
            .||..|............|:..||..|..|....|.....|      .|:.|:.. |...||||
  Fly   337 RTDKFLDKDELKVDYDSFSHHDLSNDSYSTVNLGLDEGASP------HSIRGSYM-HGSSSPSQ 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	25/67 (37%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	24/58 (41%)
		COG5576	<247..378	CDD:227863	46/143 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		7/19 (37%)
		Homeobox	270..323	CDD:395001	27/54 (50%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		11/15 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		6/13 (46%)
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	21/52 (40%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	24/54 (44%)
		Homeobox	259..312	CDD:278475	27/54 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910