DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and tup

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001286068.1	Gene:	tup / 35147	FlyBaseID:	FBgn0003896	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	390	Identity:	109/390 - (27%)
Similarity:	176/390 - (45%)	Gaps:	65/390 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    45 ISSDRAALCAGCGGKISDRYYL-LAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYR 108
            |...|.:.|.||||:|.|:|.| :|.|.:||..||||.||:..|:...|||.:||..|||.||.|
  Fly    46 IKKQRLSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVR 110

Human   109 RFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDS-LVYCRLHFEAL 172
            .|.. :|.:|....|.::.||||:..::|:.||.|:.|.:.|..||.|.::|: .:||:...:.|
  Fly   111 LFGT-KCDKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVL 174

Human   173 LQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADL 237
            .:..          .::..:::...:..:.::..|...|...|                 ..::|
  Fly   175 EKSS----------QSSLTSSSVESNNNISSSNNNNTNLSNNN-----------------HSSEL 212

Human   238 AAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQK 302
            .:.:.:.|.:.:.....|:....||..|..|:||.....||.|:::.:..|..|||...:||.:.
  Fly   213 GSMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEM 277

Human   303 TGLTKRVLQVWFQNARAKFRRNL------LRQENTGVDKSTDAALQTGTP---SGPASELSNASL 358
            |.|:.||::|||||.|.|.::..      ::||..| .|....|:| |.|   |.|....|..:|
  Fly   278 TSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKEG-RKLGYGAMQ-GIPMIASSPVRHDSPLNL 340

Human   359 SPSSTPT------TLTDL-------TSPTLPTVTSVLTSVPGNLEGHE----------PHS-PSQ 399
            ......|      .|:|.       ::..:.|.|.....:...:.|::          ||| |:|
  Fly   341 QGLDVQTYQPPWKALSDFALHADLDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQ 405

Human 400 399
Fly 406 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	30/61 (49%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	19/58 (33%)
		COG5576	<247..378	CDD:227863	42/152 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		5/19 (26%)
		Homeobox	270..323	CDD:395001	22/52 (42%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		9/15 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		6/24 (25%)
tup	NP_001286068.1	LIM1_Isl	54..108	CDD:188752	28/53 (53%)
		LIM2_Isl	116..171	CDD:188760	19/54 (35%)
		HOX	241..297	CDD:197696	23/55 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910