DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX2 and scro

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001015473.1	Gene:	scro / 3355151	FlyBaseID:	FBgn0287186	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	412	Identity:	88/412 - (21%)
Similarity:	141/412 - (34%)	Gaps:	68/412 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    16 DEMDRRAKSEAPAISSAIDRGDTET-TMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLK 79
            |.:...|.|:...:.::......|| |..::|:..||..|.....:|..::|..:..| |...|
  Fly    45 DTLIHTAISQHHQVDTSTKLNTNETSTQNTVSTAAAAAVAHHHHNLSSIHHLQNLHSQ-HQSTL- 107

Human    80 CCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLN---CF 141
                 .| .:..|.||....:...|:.||:..:.       |...|.  .|:......:|   ..
  Fly   108 -----FN-SNHSTPFSVTDILSPIEESYRKLELN-------GNPPSP--FRSNSSSSSINSPGTL 157

Human   142 TCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGA 206
            |.:|.......|..:.......||.......|.|.|....|.|....:.|.......:.|.::.|
  Fly   158 TTSTMANPYAMGTLYHSPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTANDPRFAISRLMSSSA 222

Human   207 NPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRT 271
            :          ||:        ...|..:.|||      |:.:|::.|.    :|.:|:.|| |.
  Fly   223 S----------GTM--------SHMGNMSGLAA------CSVSDSKPLQ----FPLAQRRKR-RV 258

Human   272 SFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNL-------LRQE 329
            .|...|:..::..|.......|.:.:.||....||...:::||||.|.|.:|..       ..|.
  Fly   259 LFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQH 323

Human   330 NTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPT--------VTSVLTSVP 386
            |.........|:......|.....:|:|.......|..|...:.|...        :.||..:|.
  Fly   324 NQPASSPRRVAVPVLVKDGKPCSGNNSSSQSQQHGTNSTSAGNNTGSANNGNANSGIVSVTANVS 388

Human   387 GNLE---GHEPHSPSQTTLTNL 405
            |.|.   |..|:|.|..|.::|
  Fly   389 GGLNLITGDAPNSHSPDTSSSL 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	14/62 (23%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	9/60 (15%)
		COG5576	<247..378	CDD:227863	31/145 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		6/19 (32%)
		Homeobox	270..323	CDD:395001	15/52 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		8/22 (36%)
scro	NP_001015473.1	Homeobox	256..309	CDD:278475	16/53 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910