DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and CG33521

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001014703.1	Gene:	CG33521 / 3346141	FlyBaseID:	FBgn0250819	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	56/348 - (16%)
Similarity:	107/348 - (30%)	Gaps:	121/348 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   112 VQRCARCHLGISASEMV---MRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHF---- 169
            |:.|.:|...:...|.|   ::....::|..|..|..|.|.|.. |.:.:.|..:||.:||
  Fly    77 VENCHQCKKPVYKMEEVILSLKTATTIFHKTCLRCKDCGKHLKF-DSYNVHDGSLYCSMHFKLIF 140

Human   170 --------------EALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGL-----PYYN 215
                          |.:::...|       :......|.|:....||......|.|     .:.|
  Fly   141 APKVVYEEFTPRKAELIIRENQP-------IKLPPDVAKASDKPSLGLDELQELNLRSKFKVFEN 198

Human   216 GVGTVQKGRPRKRKSPG-------------------PGADLAAYNAALSCNENDAE--------- 252
            |. .......|:|:...                   |.::|...:...|.|.:|.:
  Fly   199 GY-EEHNNNLRERQDIAITHSKSIQSTLTKFHGLGIPNSELTKLDDKNSDNNSDGDGDMNFMCLK 262

Human   253 -HLDRDQPYPSSQKTKRMRTSF--------------KHHQLRTMKSYFAINHNPDAKDLKQLA-- 300
             .::|:.|....:....:|:.|              :..:::.::|...:......|::.:||
  Fly   263 KEIERETPVGLGEAMNDIRSKFEQGDLMAKEGRREERKQEIQNIRSRLFLGKQAKIKEMYKLAVA 327

Human   301 ------QKTGLTKRVLQV--------WFQNARAKFRRNLLRQE------------NTGVDKST-- 337
                  ...|.|..:..:        .|:|........:|..|            .:|:.|::
  Fly   328 ESEQPVTSVGKTPDICAIKPTQEIKNRFENGEVYKDSKILSSEVSCGIHEDADVFESGISKASRN 392

Human   338 -----DAALQTGTPSGPASELSN 355
                 ||.:::|        |||
  Fly   393 IFMKLDANIKSG--------LSN 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	15/59 (25%)
		COG5576	<247..378	CDD:227863	24/168 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		3/29 (10%)
		Homeobox	270..323	CDD:395001	10/82 (12%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		2/23 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
CG33521	NP_001014703.1	LIM_Mical_like_2	80..136	CDD:188829	14/56 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910