DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and al

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	293	Identity:	74/293 - (25%)
Similarity:	109/293 - (37%)	Gaps:	100/293 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   176 EYP--AHFNHADV--------AAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKS 230
            |.|  |...|.|.        .::||:|.||.:..:..:|..|.|....:| ||
  Fly    11 ELPQEAKLAHPDAVVLVDRAPGSSAASAGAALTVSMSVSGGAPSGASGASG-GT----------- 63

Human   231 PGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKD 295
                      |:.:|...:|.|   .|: |...:|.:|.||:|...||..::..|:..|.||...
  Fly    64 ----------NSPVSDGNSDCE---ADE-YAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFT 114

Human   296 LKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDK--------STDAALQT----GTPSG 348
            .::||.|.|||:..:||||||.|||:|    :||..|...        ...|.:||    ..|..
  Fly   115 REELAMKIGLTEARIQVWFQNRRAKWR----KQEKVGPQSHPYNPYLPGGAATMQTVVGAALPPN 175

Human   349 PAS------------------------ELSNASLSPSS------------TPTTLTDLTSP--TL 375
            |.:                        .||.|.:.||.            .|..:..:.||  :.
  Fly   176 PFTHLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGMYSPSSSF 240

Human   376 PTVTSVLTSVP-GNLEGHEP---------HSPS 398
            .::.:.:|:|| |...|..|         |||:
  Fly   241 QSLLANMTAVPRGTPLGKPPALLVGSPDLHSPN 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	47/180 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		6/19 (32%)
		Homeobox	270..323	CDD:395001	24/52 (46%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		9/15 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		16/95 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		6/21 (29%)
al	NP_722629.1	Homeobox	89..141	CDD:278475	24/51 (47%)
al	NP_722629.1	OAR	374..391	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910