DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and CG32532

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_608318.5	Gene:	CG32532 / 32943	FlyBaseID:	FBgn0052532	Length:	688	Species:	Drosophila melanogaster

Alignment Length:	190	Identity:	51/190 - (26%)
Similarity:	80/190 - (42%)	Gaps:	55/190 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   215 NGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLR 279
            :|:.||..|    ..|||.|         ||.....|.|.......|:..: :|.||:|...||.
  Fly   473 SGLSTVSAG----ITSPGSG---------LSSLSQHAGHTPTTASCPTPAR-RRHRTTFTQEQLA 523

Human   280 TMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTG 344
            .:::.||.:|.||....::||:.|.|.:..:||||||.|||:|    :||
  Fly   524 ELEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYR----KQE--------------- 569

Human   345 TPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGN--LEGHEPHSPSQTTL 402
                  .:|..| |:||            .:|:...::.::.|.  ..|::|: |...|:
  Fly   570 ------KQLQKA-LAPS------------VIPSCNGMMRNIQGYSVSRGYQPY-PHHNTM 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	36/130 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		4/19 (21%)
		Homeobox	270..323	CDD:395001	23/52 (44%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		9/15 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		5/18 (28%)
CG32532	NP_608318.5	Homeobox	513..566	CDD:278475	23/52 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910