DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and OdsH

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_523389.3	Gene:	OdsH / 32758	FlyBaseID:	FBgn0026058	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	214	Identity:	57/214 - (26%)
Similarity:	79/214 - (36%)	Gaps:	48/214 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   171 ALLQGEYPAHFNHADVAAAAAAAAAA--------KSAGLGAAGANPLGLPYYNGVGTVQKGRPRK 227
            ||:|        .|.|||||.|....        :..|:.......:.|...:....:..|..|.
  Fly    76 ALIQ--------QARVAAAAVAMQQQQQQQRDLNRELGMDPHSEQRIKLDSVSPTHNIHAGSSRG 132

Human   228 RKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPD 292
            .|..    .|:...|..:..:||.         ..|.|.:|.||:|...|||.::..|..:|.||
  Fly   133 IKQD----PLSDEGADSNLGQNDC---------TESSKKRRGRTNFNSWQLRELERVFQGSHYPD 184

Human   293 AKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNA- 356
            ....:.||.|..|.:..:.|||||.|||:|:                  |..|..||.....||
  Fly   185 IFMREALATKLDLMEGRIAVWFQNRRAKWRK------------------QEHTKKGPGRPAHNAH 231

Human   357 SLSPSSTPTTLTDLTSPTL 375
            ..|.|..|..|::|.:..|
  Fly   232 PQSCSGDPIPLSELRAREL 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	40/130 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		4/19 (21%)
		Homeobox	270..323	CDD:395001	22/52 (42%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		8/15 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
OdsH	NP_523389.3	Homeobox	162..214	CDD:278475	22/51 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910