DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and exd

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001259592.1	Gene:	exd / 32567	FlyBaseID:	FBgn0000611	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	271	Identity:	58/271 - (21%)
Similarity:	90/271 - (33%)	Gaps:	94/271 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   187 AAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLA----AYNAAL--- 244
            ||||:||||::...|...||:          ..::....|        |.||    .|:..|
  Fly   127 AAAASAAAASQGGSLSIDGAD----------NAIEHSDYR--------AKLAQIRQIYHQELEKY 173

Human   245 --SCNE------NDAEHLDRDQP----------------YPSSQ-------------------KT 266
              :|||      |......|.:|                :.|.|                   ..
  Fly   174 EQACNEFTTHVMNLLREQSRTRPITPKEIERMVQIIHKKFSSIQMQLKQSTCEAVMILRSRFLDA 238

Human   267 KRMRTSFKHHQLRTMKSYF---AINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLR- 327
            :|.|.:|.......:..||   ..|..|..:..::||:|.|:|...:..||.|.|.::::|:.:
  Fly   239 RRKRRNFSKQASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQVSNWFGNKRIRYKKNIGKA 303

Human   328 QENTGVDKSTDAA-----LQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPG 387
            ||...:..:..||     ...|.|||                 |.|.:.||..|..:.......|
  Fly   304 QEEANLYAAKKAAGASPYSMAGPPSG-----------------TTTPMMSPAPPQDSMGYPMGSG 351

Human   388 NLEGHEPHSPS 398
            ..:..:|:..|
  Fly   352 GYDQQQPYDNS 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	37/180 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		5/54 (9%)
		Homeobox	270..323	CDD:395001	15/55 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		4/15 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		3/12 (25%)
exd	NP_001259592.1	PBC	41..237	CDD:397732	25/127 (20%)
exd	NP_001259592.1	homeodomain	239..299	CDD:238039	16/59 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910