DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and jub

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster

Alignment Length:	166	Identity:	49/166 - (29%)
Similarity:	75/166 - (45%)	Gaps:	26/166 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     7 SGP-EVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDR-YYLLAV 69
            :|| |....|:|:.|:.:.|   |..:.:.|           :...:|..||.|:... ....|:
  Fly   483 AGPTEAQRKIEELTRQLEEE---IEQSEEHG-----------EYFGICHTCGEKVKGAGQACQAM 533

Human    70 DKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDY-YRRF--SVQRCARC-HLGISASEMVMR 130
            ...:|..|..||.|...|..: ..::..|.:||:||| |..|  :.::||.| ||   ..||:::
  Fly   534 GNLYHTNCFICCSCGRALRGK-AFYNVHGRVYCEEDYMYSGFQQTAEKCAICGHL---IMEMILQ 594

Human   131 ARDLVYHLNCFTCTTCNKMLTTGDHFGMK-DSLVYC 165
            |....||..||.|..||:.| .|..|.:. |..:||
  Fly   595 AMGKSYHPGCFRCCVCNECL-DGVPFTVDVDHKIYC 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	15/63 (24%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	21/57 (37%)
		COG5576	<247..378	CDD:227863
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270
		Homeobox	270..323	CDD:395001
		Nuclear localization signal. /evidence=ECO:0000255	307..323
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	15/53 (28%)
		LIM2_Ajuba_like	581..633	CDD:188741	21/53 (40%)
		LIM3_Ajuba_like	641..702	CDD:188822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910