DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX2 and LIMK1

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	94/419 - (22%)
Similarity:	152/419 - (36%)	Gaps:	115/419 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    35 RGDTETTMPS--ISSDRAALCAGCGGKI---SDRYYLLAVDKQWHMRCLKCCECKLNLESELTCF 94
            ||.|.....|  :|...:.|||.|.|::   .:...::|:.:|||..|.:|..|:.:|.:  ..|
  Fly    13 RGGTGLGAGSGPVSGGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHN--WYF 75

Human    95 SKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMK 159
            .::|.:||:||||.||. ..|.:|...|:...||  |.:..:|..||.||.|...:..|:.:.:.
  Fly    76 EREGLLYCREDYYGRFG-DACQQCMAVITGPVMV--AGEHKFHPECFCCTACGSFIGEGESYALV 137

Human   160 D-SLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKG 223
            : |.:||     ....|:....        .|.|.|...:||........:.:|
  Fly   138 ERSKLYC-----GQCYGKRSCQ--------PADAKARITTAGKPMHSIRLVEIP----------- 178

Human   224 RPRKRKSPGPGADLAAYN--------AALSCN-----ENDAE----------------HL-DR-- 256
               |..:||...|..|.:        ..|.||     .:.||                |: ||
  Fly   179 ---KDATPGLRVDGVALDDGCPTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTNLHIGDRIL 240

Human   257 ---DQPYPSS---QKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQ 315
               ..|...|   |..|.:|::.|..||       .:.|:|                  :||...
  Fly   241 EVNGTPVSDSSVEQIDKLIRSNEKMLQL-------TVEHDP------------------VQVCRS 280

Human   316 NARAKFRRNL--------LRQENTGVDKSTDAALQT----GTPSGPASELSNAS--LSPSSTPTT 366
            .::|..:|.:        |....:.|:...:...:|    ||.:....:.:|||  :.|::..|.
  Fly   281 CSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPPAAGATA 345

Human   367 LTDLTSPTLPTVTSVLTSVPGNLEGHEPH 395
            :|.|......:..|.|.......:.|..|
  Fly   346 MTQLKEKERCSSLSKLLDEQHQAQQHSAH 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	20/67 (30%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	16/58 (28%)
		COG5576	<247..378	CDD:227863	32/174 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		9/44 (20%)
		Homeobox	270..323	CDD:395001	9/52 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		3/15 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		2/9 (22%)
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	18/56 (32%)
		LIM2_LIMK	95..148	CDD:188751	16/59 (27%)
		PDZ_signaling	172..271	CDD:238492	22/119 (18%)
		STKc_LIMK	407..693	CDD:271056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910