DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and Lim1

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_572505.1	Gene:	Lim1 / 31813	FlyBaseID:	FBgn0026411	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	308	Identity:	94/308 - (30%)
Similarity:	145/308 - (47%)	Gaps:	67/308 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    53 CAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCAR 117
            ||||...|.|::.|..:::.||..|::||||...|..:  |||::..:||:.|::||:.. :|:.
  Fly    27 CAGCNKPILDKFLLNVLERAWHASCVRCCECLQPLTDK--CFSRESKLYCRNDFFRRYGT-KCSG 88

Human   118 CHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDH-FGMKDSLVYCRLHFEALLQGEYPA-- 179
            |..||:.|::|.:.||.|:|||||||..|.|.|:||:. :.:.|:...|:   :..|.|:.|:
  Fly    89 CGQGIAPSDLVRKPRDKVFHLNCFTCCICRKQLSTGEQLYVLDDNKFICK---DDYLLGKAPSCG 150

Human   180 HFNHADVAAAAAAA---------AAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGP-- 233
            |.:.:|....:|:.         ..|.:.|||..|.|                        ||
  Fly   151 HNSLSDSLMGSASEDDDDDDPPHLRATALGLGVLGPN------------------------GPDS 191

Human   234 -GADLAAYNAALSCNENDAE--HLDRDQ--------------------PYPSSQKTKRMRTSFKH 275
             |..|...:.::.....|::  |.|.||                    ...:..|.:..||:.|.
  Fly   192 AGGPLGTSDISVQSMSTDSKNTHDDSDQGSLDGDPDGRGDSQAENKSPDDANGSKRRGPRTTIKA 256

Human   276 HQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRR 323
            .||..:|:.|.....|.....:|||::|||..||:||||||.|:|.||
  Fly   257 KQLEVLKTAFNQTPKPTRHIREQLAKETGLPMRVIQVWFQNKRSKERR 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	20/52 (38%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	23/58 (40%)
		COG5576	<247..378	CDD:227863	32/99 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		6/41 (15%)
		Homeobox	270..323	CDD:395001	24/52 (46%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		10/15 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753	20/52 (38%)
		LIM2_Lhx1_Lhx5	86..141	CDD:188761	23/57 (40%)
		COG5576	185..324	CDD:227863	38/144 (26%)
		Homeobox	250..303	CDD:278475	24/52 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910