DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and CG11294

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001259352.1	Gene:	CG11294 / 31807	FlyBaseID:	FBgn0030058	Length:	261	Species:	Drosophila melanogaster

Alignment Length:	154	Identity:	46/154 - (29%)
Similarity:	72/154 - (46%)	Gaps:	28/154 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   264 QKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRR----N 324
            ::.:|.||:|...||:.:::.|...|.||....:::|.:..|::..:||||||.|||:|:    .
  Fly    22 RRQRRNRTTFTPQQLQELEALFQKTHYPDVFLREEVALRISLSEARVQVWFQNRRAKWRKQARLQ 86

Human   325 LLRQENTGVDKSTDAALQTGTP---SGPASE--LSNASLS--PSSTPTTLTDLTSPTLPTVTSVL 382
            ||:      |......|..|||   .|.|.:  ..|.:.:  ||.||..|:..:.      .|.|
  Fly    87 LLQ------DAWRMRCLSLGTPPVMGGGAVQGGSGNGATARPPSQTPENLSSASK------DSEL 139

Human   383 TSVPGNLEGHEPHSPSQTTLTNLF 406
            ..|     |:.|:|.|.|.:...|
  Fly   140 AEV-----GNGPNSGSFTMMHPAF 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	37/124 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		1/5 (20%)
		Homeobox	270..323	CDD:395001	20/52 (38%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		9/15 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		5/18 (28%)
CG11294	NP_001259352.1	Homeobox	29..80	CDD:278475	19/50 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910