DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX2 and Vsx2

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	324	Identity:	64/324 - (19%)
Similarity:	99/324 - (30%)	Gaps:	143/324 - (44%)

- Green bases have known domain annotations that are detailed below.

Human   173 LQGEYPAHFNHADVAAAA-----AAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPG 232
            :|..:|.|.:|..:.|..     :.||.|.:...|:......|:...||.|.....:.:|:
  Fly   168 MQHHHPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFGMESLNGFGVGPNSKKKKK---- 228

Human   233 PGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLK 297
                                            |.:..||.|..:||..::..|...|.||....:
  Fly   229 --------------------------------KRRHSRTIFTSYQLEKLEEAFKEAHYPDVYARE 261

Human   298 QLAQKTGLTKRVLQVWFQNARAKFRR-----------------------------NLLR------ 327
            .|:.||.|.:..:||||||.|||:|:                             .:|:
  Fly   262 MLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDND 326

Human   328 -------------------------QENTGVDKSTDAALQTGTPSGPASELSNA----------- 356
                                     ::::||....|:|   |:.|..:.:||.:
  Fly   327 AVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDHEDSA---GSKSAHSEDLSRSRCHALSSSTES 388

Human   357 ----SLSPSSTPTTLTDLTSP--------------TLPTVTSVLTSVPGNLEGHEPH----SPS 398
                |.:|||.||:.:....|              |.||..|...|      ...||    |||
  Fly   389 LNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAATTPTGASTTNS------SSSPHIELGSPS 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	42/219 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		1/19 (5%)
		Homeobox	270..323	CDD:395001	22/52 (42%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		9/15 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		15/74 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		5/16 (31%)
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	22/52 (42%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910