DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LHX2 and vnd

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_476786.2	Gene:	vnd / 31003	FlyBaseID:	FBgn0261930	Length:	723	Species:	Drosophila melanogaster

Alignment Length:	244	Identity:	49/244 - (20%)
Similarity:	77/244 - (31%)	Gaps:	72/244 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   173 LQGEYPAHFNHADVAAAAAAAAAAK---SAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPG 234
            |.|:|.::...||..|.:...|...   |:|.|:||..|.....:|.............|:.|..
  Fly   438 LSGDYKSYSRSADSDALSVGDALHTLHGSSGNGSAGGAPTAHALHNNNNNTTNNNNHSLKAEGIN 502

Human   235 ADLAAYNAALSCN--ENDAEHLD-----------RDQPYPSSQKTKRMRTSFKHHQLRTMKSYFA 286
            ...:.::.:|:.:  |.|.:.:|           .....|:  |.::.|..|...|...::..|.
  Fly   503 GAGSGHDDSLNEDGIEEDIDDVDDADGSGGGDANGSDGLPN--KKRKRRVLFTKAQTYELERRFR 565

Human   287 INHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPAS 351
            ......|.:.:.||....||...:::||||.|.|.:|   .|...|.:
  Fly   566 QQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKR---AQNEKGYE----------------- 610

Human   352 ELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGH--EPHSPS 398
                                            ..||.|.||  .||.||
  Fly   611 --------------------------------GHPGLLHGHATHPHHPS 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	23/143 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		4/30 (13%)
		Homeobox	270..323	CDD:395001	15/52 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		2/45 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		8/14 (57%)
vnd	NP_476786.2	Homeobox	548..601	CDD:278475	15/52 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910