DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LHX2 and CG30178

DIOPT Version :9

Sequence 1:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_726395.1	Gene:	CG30178 / 246501	FlyBaseID:	FBgn0050178	Length:	187	Species:	Drosophila melanogaster

Alignment Length:	162	Identity:	43/162 - (26%)
Similarity:	69/162 - (42%)	Gaps:	18/162 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     4 HSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLA 68
            |..:..|...|:|          |.:..|:|  |............||.|:.|...|.:| .:.|
  Fly    28 HHFTCKECGLVVD----------PKLFFAVD--DDVVCSECYLDKHAARCSACRTPILER-GVAA 79

Human    69 VDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARD 133
            .:::||.:|.:|..|..:|.| .:.|..:|.::||..:...|| .|||.|...|....:|  |..
  Fly    80 AERKWHEKCFRCVSCSKSLVS-ASFFEVNGYLFCKAHFRELFS-SRCAGCEKPIDRRAVV--ALS 140

Human   134 LVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYC 165
            ..:|..||.|..|.|.::..: |.:::....|
  Fly   141 TKWHAKCFKCHHCRKRISARE-FWIENGQPIC 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853	18/62 (29%)
		LIM2_Lhx2_Lhx9	111..169	CDD:188763	16/55 (29%)
		COG5576	<247..378	CDD:227863
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270
		Homeobox	270..323	CDD:395001
		Nuclear localization signal. /evidence=ECO:0000255	307..323
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
CG30178	NP_726395.1	LIM	6..61	CDD:295319	8/44 (18%)
		LIM	65..116	CDD:259829	16/52 (31%)
		LIM	124..171	CDD:295319	13/49 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910