DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLIT2 and slit2

DIOPT Version :9

Sequence 1:	XP_005248268.1	Gene:	SLIT2 / 9353	HGNCID:	11086	Length:	1533	Species:	Homo sapiens
Sequence 2:	XP_021331524.1	Gene:	slit2 / 80353	ZFINID:	ZDB-GENE-010306-3	Length:	1551	Species:	Danio rerio

Alignment Length:	1554	Identity:	1227/1554 - (78%)
Similarity:	1379/1554 - (88%)	Gaps:	31/1554 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     8 MLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITK 72
            |..|...::.|:|.....|:||:||||||:.|||||.:|||||||||||.||||||.||:|:|||
Zfish     1 MFVLKSVVLCALLCGAGAQSCPSQCSCSGTAVDCHGQSLRSVPRNIPRNVERLDLNANNLTKITK 65

Human    73 TDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSEN 137
            .|||||::||||||||||||:|||||||||:||||||||||:||:.||||||||.||:|||||||
Zfish    66 ADFAGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNNLQVLPELLFLGTTKLFRLDLSEN 130

Human   138 QIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLR 202
            |||.||||||||:.:|||||||||||||||||||||||||||||||||||:||||||||||||||
Zfish   131 QIQGIPRKAFRGSTEIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNISRLSVASFNHMPKLR 195

Human   203 TFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSF 267
            |||||||||.|||::||||||||||||:|||||||.|..|||||:|||||:||:|:|..||.||.
Zfish   196 TFRLHSNNLLCDCNVAWLSDWLRQRPRLGLYTQCMAPPSLRGHNIAEVQKKEFMCTDFSEGPQSH 260

Human   268 MAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRR 332
              .|||||.||..||||||:|||||||||||||||||||||||||||:||:||.|||:|||:|||
Zfish   261 --SSCSVLQCPELCTCSNNVVDCRGKGLTEIPTNLPETITEIRLEQNSIKIIPAGAFAPYKRLRR 323

Human   333 IDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQ 397
            ||||||||:|||.|:||||||||||||||||||||||.||:|||||||||||||||||||||:||
Zfish   324 IDLSNNQITELASDSFQGLRSLNSLVLYGNKITELPKGLFDGLFSLQLLLLNANKINCLRVDSFQ 388

Human   398 DLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCT 462
            ||.|||||||||||||||||||||.||||||:|||||||:||||||||||||..|||||||||||
Zfish   389 DLQNLNLLSLYDNKLQTIAKGTFSSLRAIQTLHLAQNPFMCDCHLKWLADYLQDNPIETSGARCT 453

Human   463 SPRRLANKRIGQIKSKKFRCSAKEQYFIPG-------TEDYRSKLSGDCFADLACPEKCRCEGTT 520
            ||||||||||||||||||||||||||||||       .|||||||.|||||||||||||||||||
Zfish   454 SPRRLANKRIGQIKSKKFRCSAKEQYFIPGIHHINKCVEDYRSKLGGDCFADLACPEKCRCEGTT 518

Human   521 VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGA 585
            ||||.|||.|||:|||||||||||||||||||||||||||||||||||.|||||||||||.||||
Zfish   519 VDCSGQKLTKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGTFEGA 583

Human   586 SGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVA 650
            |||||::|||||||.|.:.|.|||..|:|||||||||:||.|.||.|||||||||||||.||:::
Zfish   584 SGVNELILTSNRLEGVHYSMLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMS 648

Human   651 PGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFT 715
            ||||||||||||||||||||||||:|||||||||||||||||||||.|||||||||||||:|||.
Zfish   649 PGAFDTLHSLSTLNLLANPFNCNCHLAWLGEWLRKKRIVTGNPRCQSPYFLKEIPIQDVAVQDFA 713

Human   716 CDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY 780
            |::|||:||||||:|||.||:||||||||||||||||||||||||||||||||:||.||.|||||
Zfish   714 CEEGNDENSCSPLARCPAECSCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNEFTQVPLELSNY 778

Human   781 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVP 845
            |||||||||||:||||||.|||||::|||||||||||||||.:.|||||||||||||||||:|:|
Zfish   779 KHLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRLRCIPAKAFDGLKSLRLLSLHGNDIAVIP 843

Human   846 EGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFT 910
            :|||.|||:|||||:|||||||||:||||||||||.|||||||||.|||:|.|||||||||||||
Zfish   844 DGAFKDLSSLSHLALGANPLYCDCHMQWLSDWVKSGYKEPGIARCTGPGDMTDKLLLTTPSKKFT 908

Human   911 C-----------QGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA 964
            |           .|||||:|||||||||||||||||||::.||||||||||||||||||:.||||
Zfish   909 CTEVPGTCGFPVPGPVDVSILAKCNPCLSNPCKNDGTCSNHPVDFYRCTCPYGFKGQDCEEPIHA 973

Human   965 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCP 1029
            ||||||::|||||||:|||:..||:|.:||||:.||:|:|||||||||||||||||||||||||.
Zfish   974 CISNPCQNGGTCHLKDGEENTHWCVCPEGFEGDECEINIDDCEDNDCENNSTCVDGINNYTCLCS 1038

Human  1030 PEYT---------GELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQ 1085
            ||||         |||||:||||||.:||.||||||||||.|||.|:|||||.||||::|||||:
Zfish  1039 PEYTAANNNEVEKGELCEDKLDFCASELNLCQHDSKCILTAKGFMCECTPGYTGEHCEVDFDDCE 1103

Human  1086 DNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQ 1150
            ||||||||.|.||||||||:|||||||||||||||||||||||||::||.|||||:|:..:|:||
Zfish  1104 DNKCKNGAQCIDAVNGYTCVCPEGYSGLFCEFSPPMVLPRTSPCDHYDCANGAQCVVKDTDPVCQ 1168

Human  1151 CLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELY 1215
            |||||:|..||:||||||||:||:|||||..:..|.||:||||||||:|:||||||.:|||||||
Zfish  1169 CLPGYEGVHCERLVSVNFINRESFLQIPSNLITEQANISLQIATDEDNGVLLYKGDNEHIAVELY 1233

Human  1216 RGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFD 1280
            |||:|.|||:||:|.||||||||||||:||:|||:|.|||||||:|||:||.|...:..|.:...
Zfish  1234 RGRLRVSYDSGSYPPSAIYSVETINDGSFHVVELVAKDQSLSLSIDGGSPKSINTANSPSPVPSP 1298

Human  1281 SPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVC 1345
            :|||:||:|.:|.:|||||..|:||:||||||||||||.:|||..:..:|.|::|||:||.:.:|
Zfish  1299 APLYLGGLPQQSGLASLRQGSGRNGSSFHGCIRNLYINDQLQDLTQFLLQEGVVPGCQPCQRSMC 1363

Human  1346 AHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLC 1410
            |||.|..:.|:.|:|||:.||.||||||:.|:||.||||:||:|:.||::||||:||.|..||||
Zfish  1364 AHGQCHATGQSSFSCECEAGWTGPLCDQQVNNPCDGNKCIHGSCMAINSYSYSCRCLPGFAGVLC 1428

Human  1411 DEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAAC 1475
            ||||.| :|||.|.||:|:||:||||:.||||:|||||.|||||::|||||:||:||.|||||||
Zfish  1429 DEEEQL-SPCQYIACKYGRCRVSGLGKAYCECNSGYTGQSCDREMACRGERVRDHYQTQQGYAAC 1492

Human  1476 QTTKKVSRLECRGGCAGG-QCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS 1533
            |:|:|||||||||.|..| .||.|||||||||:|:||||||||.|||||||||||:|.|
Zfish  1493 QSTEKVSRLECRGSCGDGTSCCAPLRSKRRKYTFQCTDGSSFVQEVEKVVKCGCTKCPS 1551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLIT2	XP_005248268.1	LRRNT	27..58	CDD:214470	24/30 (80%)
		leucine-rich repeat	38..56	CDD:275380	14/17 (82%)
		LRR_8	55..115	CDD:404697	50/59 (85%)
		leucine-rich repeat	57..80	CDD:275380	17/22 (77%)
		internalin_A	73..>434	CDD:380193	309/360 (86%)
		leucine-rich repeat	81..104	CDD:275380	21/22 (95%)
		leucine-rich repeat	105..128	CDD:275380	19/22 (86%)
		leucine-rich repeat	129..152	CDD:275380	19/22 (86%)
		leucine-rich repeat	153..176	CDD:275380	22/22 (100%)
		LRR_8	154..211	CDD:404697	55/56 (98%)
		leucine-rich repeat	177..200	CDD:275380	21/22 (95%)
		leucine-rich repeat	201..329	CDD:275380	101/127 (80%)
		LRR_8	307..364	CDD:404697	48/56 (86%)
		leucine-rich repeat	330..353	CDD:275380	19/22 (86%)
		leucine-rich repeat	354..374	CDD:275380	18/19 (95%)
		leucine-rich repeat	378..401	CDD:275380	21/22 (95%)
		leucine-rich repeat	402..423	CDD:275380	20/20 (100%)
		PCC	407..>470	CDD:188093	57/62 (92%)
		leucine-rich repeat	426..527	CDD:275380	93/107 (87%)
		LRRNT	509..539	CDD:214470	26/29 (90%)
		leucine-rich repeat	541..563	CDD:275380	21/21 (100%)
		internalin_A	561..>858	CDD:380193	251/296 (85%)
		leucine-rich repeat	564..587	CDD:275380	20/22 (91%)
		leucine-rich repeat	588..611	CDD:275380	15/22 (68%)
		leucine-rich repeat	612..635	CDD:275380	17/22 (77%)
		leucine-rich repeat	636..659	CDD:275380	18/22 (82%)
		leucine-rich repeat	660..751	CDD:275380	80/90 (89%)
		leucine-rich repeat	752..782	CDD:275380	26/29 (90%)
		LRR_8	782..841	CDD:404697	51/58 (88%)
		leucine-rich repeat	783..806	CDD:275380	20/22 (91%)
		leucine-rich repeat	807..830	CDD:275380	19/22 (86%)
		leucine-rich repeat	831..852	CDD:275380	16/20 (80%)
		PCC	836..>1017	CDD:188093	149/191 (78%)
		leucine-rich repeat	855..867	CDD:275378	10/11 (91%)
		EGF_CA	1002..1038	CDD:238011	33/44 (75%)
		EGF_CA	1042..1077	CDD:238011	27/34 (79%)
		EGF_CA	1080..1116	CDD:238011	31/35 (89%)
		hEGF	1134..1155	CDD:403759	13/20 (65%)
		LamG	1187..1320	CDD:214598	93/132 (70%)
slit2	XP_021331524.1	LRRNT	21..51	CDD:214470	24/29 (83%)
		leucine-rich repeat	32..49	CDD:275380	14/16 (88%)
		LRR_8	48..108	CDD:316378	50/59 (85%)
		leucine-rich repeat	50..73	CDD:275380	17/22 (77%)
		leucine-rich repeat	74..97	CDD:275380	21/22 (95%)
		LRR_8	97..156	CDD:316378	49/58 (84%)
		leucine-rich repeat	98..121	CDD:275380	19/22 (86%)
		leucine-rich repeat	122..145	CDD:275380	19/22 (86%)
		LRR_8	144..204	CDD:316378	56/59 (95%)
		leucine-rich repeat	146..169	CDD:275380	22/22 (100%)
		leucine-rich repeat	170..193	CDD:275380	21/22 (95%)
		PCC	175..>237	CDD:188093	53/61 (87%)
		leucine-rich repeat	194..320	CDD:275380	101/127 (80%)
		LRRNT	267..299	CDD:214470	27/31 (87%)
		LRR_8	298..355	CDD:316378	48/56 (86%)
		leucine-rich repeat	321..344	CDD:275380	19/22 (86%)
		leucine-rich repeat	345..365	CDD:275380	18/19 (95%)
		LRR_8	375..427	CDD:316378	47/51 (92%)
		leucine-rich repeat	393..416	CDD:275380	21/22 (95%)
		PCC	398..>461	CDD:188093	57/62 (92%)
		LRRNT	507..537	CDD:214470	26/29 (90%)
		leucine-rich repeat	517..535	CDD:275380	14/17 (82%)
		leucine-rich repeat	539..561	CDD:275380	21/21 (100%)
		LRR_8	560..620	CDD:316378	47/59 (80%)
		leucine-rich repeat	562..585	CDD:275380	20/22 (91%)
		leucine-rich repeat	586..609	CDD:275380	15/22 (68%)
		LRR_8	609..668	CDD:316378	48/58 (83%)
		leucine-rich repeat	610..633	CDD:275380	17/22 (77%)
		leucine-rich repeat	634..657	CDD:275380	18/22 (82%)
		PCC	639..>716	CDD:188093	68/76 (89%)
		leucine-rich repeat	658..780	CDD:275380	108/121 (89%)
		leucine-rich repeat	677..728	CDD:275380	44/50 (88%)
		NEL	<698..>863	CDD:330839	140/164 (85%)
		leucine-rich repeat	736..757	CDD:275380	20/20 (100%)
		LRR_8	780..839	CDD:316378	51/58 (88%)
		leucine-rich repeat	781..804	CDD:275380	20/22 (91%)
		leucine-rich repeat	805..828	CDD:275380	19/22 (86%)
		leucine-rich repeat	829..850	CDD:275380	16/20 (80%)
		PCC	834..>1026	CDD:188093	149/191 (78%)
		EGF	1015..1042	CDD:306513	25/26 (96%)
		EGF_CA	1060..1096	CDD:238011	28/35 (80%)
		EGF_CA	1098..1134	CDD:238011	31/35 (89%)
		Laminin_G_2	1210..1338	CDD:308045	89/127 (70%)
		GHB_like	1489..1550	CDD:328788	48/60 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327496
Domainoid	1	1.000	284	1.000	Domainoid score	I8078
eggNOG	1	0.900	-	-		E2759_KOG4237
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3516
Inparanoid	1	1.050	2621	1.000	Inparanoid score	I230
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45950
OrthoDB	1	1.010	-	-		D19272at7742
OrthoFinder	1	1.000	-	-		FOG0001593
OrthoInspector	1	1.000	-	-		oto42591
orthoMCL	1	0.900	-	-		OOG6_103623
Panther	1	1.100	-	-	LDO	PTHR45836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1145
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.270