DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SLIT2 and Toll-6

DIOPT Version :9

Sequence 1:XP_005248268.1 Gene:SLIT2 / 9353 HGNCID:11086 Length:1533 Species:Homo sapiens
Sequence 2:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:1634 Identity:337/1634 - (20%)
Similarity:530/1634 - (32%) Gaps:609/1634 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    58 ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKI------STIERGAFQDLKELERLRLNRNHLQ 116
            ::|.:....:.|:.:....||..||.|.|..:.|      ..||..||...:.||||.|:.|::.
  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213

Human   117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRG-----------------------------AVD 152
            ..|:.:|...::|..|::|||::|.:....||.                             ::|
  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278

Human   153 IKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHL 217
            ::.|.:.:|....:....|..||.|.||::|||.|:.::..:.:.:..|:...|.||.       
  Fly   279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNK------- 336

Human   218 AWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACT 282
                                                                             
  Fly   337 ----------------------------------------------------------------- 336

Human   283 CSNNIVDCRGKGLTEIPTNL----PETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISEL 343
                        :..:||.|    .:.|.|:.|:.|:|.|:.|..||...:|:.:|||.|||:. 
  Fly   337 ------------IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS- 388

Human   344 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLY 408
                                 |.:.|:.|.||..|.||.|:.||:..|..:.|.||:.|.:|:|.
  Fly   389 ---------------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLR 432

Human   409 DNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIG 473
            .|:|:.||..||:|:..:.|:.|:.|      .||:|..|      ..:|....|...|.|..:.
  Fly   433 HNQLENIAADTFAPMNNLHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALI 485

Human   474 QIKSKKFR-CSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHI-- 535
            .:....|| |||.:...:.|.:                                 |..:|..:  
  Fly   486 GVHPDAFRNCSALQDLNLNGNQ---------------------------------LKTVPLALRN 517

Human   536 PQYTAELRLNNNEFTVLEATGI-----------------------FKKLPQLRKINFSNNKITDI 577
            .::...:.|..|..||:|.:..                       |:.||.|:.:|.:.|:|..:
  Fly   518 MRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVV 582

Human   578 EEGAFEGASGVNEILLTSNRLENVQHKMFKGLES----------------------LKTLMLRSN 620
            |.||||..|.:..:.|..|.|.:: :.:|..:.|                      |:.|.|..|
  Fly   583 EPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKN 646

Human   621 RITCVGN----DSFIGL-------------------SSVRLLSLYDNQITTVAPGAFDTLHSLST 662
            |::.:.|    ||.:.|                   :|:.||.|.||.||||.|..|....:|:.
  Fly   647 RLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTR 711

Human   663 LNLLA-----------------------------NPFNCNCYLAWLGEWLRKKRIVTGN--PR-- 694
            ::|.|                             |||.|:|.:    :||:|...:|..  ||  
  Fly   712 VDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNI----DWLQKINHITSRQYPRIM 772

Human   695 ------C------QKPYFLKEIPIQDVAIQDFTCDDGN---------DDNSCSPLSRCPTECTCL 738
                  |      ::.|    ||:.:...:.|.|....         :.::|.....|||.|||.
  Fly   773 DLETIYCKLLNNRERAY----IPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCF 833

Human   739 ------DTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY-----KHLTLIDLSNNR 792
                  ..:|.||......:|:.:|.|.:|||:|||.|.    ||:.:     |:|.::..:|:.
  Fly   834 HDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFV----ELAGHSFLGRKNLAVLYANNSN 894

Human   793 ISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSH 857
            ::.:.|.:||.:.:||.|.|..|.:..:....|..|::||.|.|..|.|:.:..|:|..|..|..
  Fly   895 VAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEV 959

Human   858 LAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAK 922
            |.:..|      .:.....|..|                                          
  Fly   960 LRLDGN------RLMHFEVWQLS------------------------------------------ 976

Human   923 CNPCLSNPCKNDGTCNSDPVDFYRCTCPY-----GFKGQDCDVPIHA----CISNPC------KH 972
            .||.|......|..        :.|.|.|     .:.||..:..|.|    ||.|..      |:
  Fly   977 ANPYLVEISLADNQ--------WSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKN 1033

Human   973 GGTCHLKEG--------EEDGFW-----CICA-DGFEG------------------ENCEVNVDD 1005
            |..|.|::|        |.:|..     ..|| ..|.|                  .||.:|.  
  Fly  1034 GTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNF-- 1096

Human  1006 CEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK-----LDFCAQDLNPCQHDSKCILTPKGFK 1065
                                |...|.:..:|.:|:     ..:..||    :|....||      
  Fly  1097 --------------------CYKSPRFVDQLDKERPNDAYFAYSLQD----EHFVNQIL------ 1131

Human  1066 CDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAV-------NGYTCICPEGYSGLFCEFS----- 1118
            .......:|....:.:.|...|     |:.|||:       ..:..:..:.:  |:.|:|     
  Fly  1132 AQTLENDIGYRLCLHYRDVNIN-----AYITDALIEAAESAKQFVLVLSKNF--LYNEWSRFEYK 1189

Human  1119 ---PPMV-------------LP------------RTSPCDNFDCQNGAQCIVRINEPICQCLPGY 1155
               ..:|             ||            |||.|..:|.:...|.: |:..|    ||..
  Fly  1190 SALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDDKKFWQKL-RLALP----LPNG 1249

Human  1156 QGEKCEKLV---------SVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIA 1211
            :|...:::|         |||........|..:..|.|..:     |...|.|...|....:..|
  Fly  1250 RGNNNKRVVSGCLSGRTPSVNMYATSHEYQAGNGGVIPPPS-----ARYADCGSNNYATINECAA 1309

Human  1212 VELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQST 1276
            ..  .||......|.:..|:|.....|:|.        |:..|...|||.|        ::|   
  Fly  1310 AG--GGRGYKPIPTSASAAAAACKFNTMNQ--------LSKKQQRDLSVAG--------MAK--- 1353

Human  1277 LNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCH 1341
                                         |..|....|...|...|....||   ..||...|.:
  Fly  1354 -----------------------------TLEHQHHHNHQANRRSQHEYAVP---SYLPSAAPAY 1386

Human  1342 KKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLG-NKCVHGTCLPINAFSYSCK----C 1401
            ..| .:...|..:.|  .|||..  :|........:|..| ........:|....||:||    |
  Fly  1387 DSV-DYAKQQIRNNA--NCECVN--LGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKKSCSC 1446

Human  1402 LEGHGGVLC 1410
            : |...:||
  Fly  1447 I-GDDELLC 1454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLIT2XP_005248268.1 LRRNT 27..58 CDD:214470 337/1634 (21%)
leucine-rich repeat 38..56 CDD:275380
LRR_8 55..115 CDD:404697 19/62 (31%)
leucine-rich repeat 57..80 CDD:275380 4/21 (19%)
internalin_A 73..>434 CDD:380193 90/399 (23%)
leucine-rich repeat 81..104 CDD:275380 9/28 (32%)
leucine-rich repeat 105..128 CDD:275380 8/22 (36%)
leucine-rich repeat 129..152 CDD:275380 8/51 (16%)
leucine-rich repeat 153..176 CDD:275380 4/22 (18%)
LRR_8 154..211 CDD:404697 16/56 (29%)
leucine-rich repeat 177..200 CDD:275380 7/22 (32%)
leucine-rich repeat 201..329 CDD:275380 16/131 (12%)
LRR_8 307..364 CDD:404697 15/56 (27%)
leucine-rich repeat 330..353 CDD:275380 7/22 (32%)
leucine-rich repeat 354..374 CDD:275380 3/19 (16%)
leucine-rich repeat 378..401 CDD:275380 10/22 (45%)
leucine-rich repeat 402..423 CDD:275380 9/20 (45%)
PCC 407..>470 CDD:188093 18/62 (29%)
leucine-rich repeat 426..527 CDD:275380 17/101 (17%)
LRRNT 509..539 CDD:214470 2/31 (6%)
leucine-rich repeat 541..563 CDD:275380 7/44 (16%)
internalin_A 561..>858 CDD:380193 103/406 (25%)
leucine-rich repeat 564..587 CDD:275380 9/22 (41%)
leucine-rich repeat 588..611 CDD:275380 4/22 (18%)
leucine-rich repeat 612..635 CDD:275380 9/45 (20%)
leucine-rich repeat 636..659 CDD:275380 11/22 (50%)
leucine-rich repeat 660..751 CDD:275380 30/150 (20%)
leucine-rich repeat 752..782 CDD:275380 12/34 (35%)
LRR_8 782..841 CDD:404697 17/58 (29%)
leucine-rich repeat 783..806 CDD:275380 5/22 (23%)
leucine-rich repeat 807..830 CDD:275380 7/22 (32%)
leucine-rich repeat 831..852 CDD:275380 8/20 (40%)
PCC 836..>1017 CDD:188093 39/227 (17%)
leucine-rich repeat 855..867 CDD:275378 3/11 (27%)
EGF_CA 1002..1038 CDD:238011 4/35 (11%)
EGF_CA 1042..1077 CDD:238011 6/34 (18%)
EGF_CA 1080..1116 CDD:238011 7/42 (17%)
hEGF 1134..1155 CDD:403759 5/20 (25%)
LamG 1187..1320 CDD:214598 23/132 (17%)
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 4/21 (19%)
LRR_8 171..236 CDD:290566 22/64 (34%)
leucine-rich repeat 172..201 CDD:275380 9/28 (32%)
leucine-rich repeat 202..278 CDD:275380 16/75 (21%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
LRR_RI 278..468 CDD:238064 68/307 (22%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR_8 301..386 CDD:290566 29/168 (17%)
leucine-rich repeat 303..326 CDD:275380 7/22 (32%)
leucine-rich repeat 327..350 CDD:275380 7/106 (7%)
LRR 350..729 CDD:227223 107/446 (24%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 12/46 (26%)
LRR_RI <401..626 CDD:238064 62/270 (23%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 10/22 (45%)
leucine-rich repeat 450..473 CDD:275380 8/34 (24%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 3/52 (6%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 1/20 (5%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 4/22 (18%)
leucine-rich repeat 616..637 CDD:275380 0/20 (0%)
leucine-rich repeat 638..662 CDD:275380 8/23 (35%)
leucine-rich repeat 663..684 CDD:275380 1/20 (5%)
leucine-rich repeat 685..708 CDD:275380 11/22 (50%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR_8 883..943 CDD:290566 18/59 (31%)
leucine-rich repeat 885..908 CDD:275380 5/22 (23%)
leucine-rich repeat 909..932 CDD:275380 7/22 (32%)
LRR_8 932..990 CDD:290566 18/105 (17%)
leucine-rich repeat 933..956 CDD:275380 9/22 (41%)
TIR 1114..1247 CDD:214587 26/154 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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