DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLIT2 and slit2

DIOPT Version :9

Sequence 1:	XP_005248268.1	Gene:	SLIT2 / 9353	HGNCID:	11086	Length:	1533	Species:	Homo sapiens
Sequence 2:	XP_031751209.1	Gene:	slit2 / 100492007	XenbaseID:	XB-GENE-1004410	Length:	1543	Species:	Xenopus tropicalis

Alignment Length:	1539	Identity:	1349/1539 - (87%)
Similarity:	1446/1539 - (93%)	Gaps:	17/1539 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     4 VGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNIT 68
            :|:..||:||||||..|::||||.|||||||:|:|||||||.||||||||||||||||||.||||
Frog    13 IGFWKLSVSLGLVLVTLSEVAPQPCPAQCSCTGTTVDCHGLTLRSVPRNIPRNTERLDLNANNIT 77

Human    69 RITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLD 133
            ||:|||||||||||:||||||||:|||||||||||||||||||||:||:|||||||||.||||||
Frog    78 RISKTDFAGLRHLRILQLMENKITTIERGAFQDLKELERLRLNRNNLQVFPELLFLGTPKLYRLD 142

Human   134 LSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHM 198
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   143 LSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHM 207

Human   199 PKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEG 263
            |||||||||||||||||||||||||||||||||||||||||.||||||:||||||||||:|||||
Frog   208 PKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPIHLRGHNIAEVQKREFVCTDEEEG 272

Human   264 HQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYK 328
            .||||..||||||||||||||||||||||||||||||||||||||:|||||:|||||||||||||
Frog   273 QQSFMVHSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEMRLEQNSIKVIPPGAFSPYK 337

Human   329 KLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRV 393
            ||||||||||||||:|.||||||||||||||||||||||||.|||||..||||||||||||||||
Frog   338 KLRRIDLSNNQISEIAADAFQGLRSLNSLVLYGNKITELPKGLFEGLVLLQLLLLNANKINCLRV 402

Human   394 DAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSG 458
            |:|||||||||||||||||||||||||:|||||||:|||||||||||||||||||||||||||||
Frog   403 DSFQDLHNLNLLSLYDNKLQTIAKGTFAPLRAIQTLHLAQNPFICDCHLKWLADYLHTNPIETSG 467

Human   459 ARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDC 523
            |||||||||||||||||||||||||        ||||||||||||||||||||||||||||||||
Frog   468 ARCTSPRRLANKRIGQIKSKKFRCS--------GTEDYRSKLSGDCFADLACPEKCRCEGTTVDC 524

Human   524 SNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGV 588
            |||||.|||:|||||||||||||||||||||||||||||||||||.||||||||||||||||:||
Frog   525 SNQKLTKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGAFEGANGV 589

Human   589 NEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGA 653
            ||:||||||:|||:||||||||.|||||||||||:||.||||.||||||||||||||||||||||
Frog   590 NELLLTSNRMENVRHKMFKGLEGLKTLMLRSNRISCVNNDSFTGLSSVRLLSLYDNQITTVAPGA 654

Human   654 FDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDD 718
            |||||||||||||||||||||:|||||:|||||||||||||||||||||||||||||||||||||
Frog   655 FDTLHSLSTLNLLANPFNCNCHLAWLGDWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDD 719

Human   719 GNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHL 783
            ||:|||||||||||.|||||||||||||||||.||||||::|||||||||.|.||||||||||||
Frog   720 GNEDNSCSPLSRCPAECTCLDTVVRCSNKGLKSLPKGIPKEVTELYLDGNMFPLVPKELSNYKHL 784

Human   784 TLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGA 848
            |||||||||||||||.||||||||||||||||||||||.|.||||||||||||||||:|.:||||
Frog   785 TLIDLSNNRISTLSNHSFSNMTQLLTLILSYNRLRCIPLRAFDGLKSLRLLSLHGNDVSAIPEGA 849

Human   849 FNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQG 913
            |||||:||||||||||||||||:|||||||||||||||||||:||||||||||||||||||||.|
Frog   850 FNDLSSLSHLAIGANPLYCDCNLQWLSDWVKSEYKEPGIARCSGPGEMADKLLLTTPSKKFTCNG 914

Human   914 PVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHL 978
            ||||:||||||||||||||||||||:|||:|||||||||||||||||||||||||||::.|||||
Frog   915 PVDVSILAKCNPCLSNPCKNDGTCNNDPVEFYRCTCPYGFKGQDCDVPIHACISNPCRNSGTCHL 979

Human   979 KEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYT---------G 1034
            |||::|||||.||:||||||||||:|||||||||||||||||||||||.||||||         |
Frog   980 KEGDKDGFWCACAEGFEGENCEVNIDDCEDNDCENNSTCVDGINNYTCRCPPEYTAAKLNEVEKG 1044

Human  1035 ELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAV 1099
            ||||||||||:||:||||||||||||.||:||||||||:|||||||:||||:|||:|||.|.|||
Frog  1045 ELCEEKLDFCSQDVNPCQHDSKCILTLKGYKCDCTPGYIGEHCDIDYDDCQENKCRNGARCVDAV 1109

Human  1100 NGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLV 1164
            |||||:|||||||||||.:||||||||||||||:|||||||||:.|||.|||||||.|.||||||
Frog  1110 NGYTCVCPEGYSGLFCESAPPMVLPRTSPCDNFECQNGAQCIVKGNEPQCQCLPGYHGNKCEKLV 1174

Human  1165 SVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHP 1229
            ||||:||:|::||||||:|.|.|||||:||||||||||||||||.:||||||||||.|||||.:|
Frog  1175 SVNFVNKDSFIQIPSAKIRTQANITLQVATDEDSGILLYKGDKDQVAVELYRGRVRVSYDTGINP 1239

Human  1230 ASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNV 1294
            ||||||||||||||||:|||:.|||:|||.||||.||.||||.|||.::.||.||:||||.|:|:
Frog  1240 ASAIYSVETINDGNFHVVELVNLDQTLSLVVDGGTPKSITNLPKQSLISIDSTLYIGGMPMKNNI 1304

Human  1295 ASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFT 1359
            |.|||:..||||:|.|||||||||:|||||:|:.:|.|:||||||||||||.||||..:||||||
Frog  1305 AGLRQSSSQNGTNFLGCIRNLYINNELQDFRKLNLQAGVLPGCEPCHKKVCVHGTCLATSQAGFT 1369

Human  1360 CECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIK 1424
            |||:.||.|.|||.::||||||||||||||||||:||||||||:|..||||||.||..||||:||
Frog  1370 CECEGGWTGQLCDIQSNDPCLGNKCVHGTCLPINSFSYSCKCLQGFVGVLCDEPEDQPNPCQSIK 1434

Human  1425 CKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGG 1489
            ||||||||||||:.||||:|||||||||:||||||||:|||||:||||||||||:|||||||:||
Frog  1435 CKHGKCRLSGLGKAYCECNSGYTGDSCDKEISCRGERVRDYYQRQQGYAACQTTEKVSRLECKGG 1499

Human  1490 CAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS 1533
            |:.||||||||||||||:||||||||||||||||:|||||:|.|
Frog  1500 CSNGQCCGPLRSKRRKYAFECTDGSSFVDEVEKVIKCGCTKCPS 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLIT2	XP_005248268.1	LRRNT	27..58	CDD:214470	26/30 (87%)
		leucine-rich repeat	38..56	CDD:275380	16/17 (94%)
		LRR_8	55..115	CDD:404697	55/59 (93%)
		leucine-rich repeat	57..80	CDD:275380	20/22 (91%)
		internalin_A	73..>434	CDD:380193	339/360 (94%)
		leucine-rich repeat	81..104	CDD:275380	20/22 (91%)
		leucine-rich repeat	105..128	CDD:275380	20/22 (91%)
		leucine-rich repeat	129..152	CDD:275380	22/22 (100%)
		leucine-rich repeat	153..176	CDD:275380	22/22 (100%)
		LRR_8	154..211	CDD:404697	56/56 (100%)
		leucine-rich repeat	177..200	CDD:275380	22/22 (100%)
		leucine-rich repeat	201..329	CDD:275380	119/127 (94%)
		LRR_8	307..364	CDD:404697	52/56 (93%)
		leucine-rich repeat	330..353	CDD:275380	20/22 (91%)
		leucine-rich repeat	354..374	CDD:275380	18/19 (95%)
		leucine-rich repeat	378..401	CDD:275380	21/22 (95%)
		leucine-rich repeat	402..423	CDD:275380	19/20 (95%)
		PCC	407..>470	CDD:188093	60/62 (97%)
		leucine-rich repeat	426..527	CDD:275380	91/100 (91%)
		LRRNT	509..539	CDD:214470	27/29 (93%)
		leucine-rich repeat	541..563	CDD:275380	21/21 (100%)
		internalin_A	561..>858	CDD:380193	271/296 (92%)
		leucine-rich repeat	564..587	CDD:275380	21/22 (95%)
		leucine-rich repeat	588..611	CDD:275380	19/22 (86%)
		leucine-rich repeat	612..635	CDD:275380	19/22 (86%)
		leucine-rich repeat	636..659	CDD:275380	22/22 (100%)
		leucine-rich repeat	660..751	CDD:275380	86/90 (96%)
		leucine-rich repeat	752..782	CDD:275380	25/29 (86%)
		LRR_8	782..841	CDD:404697	55/58 (95%)
		leucine-rich repeat	783..806	CDD:275380	21/22 (95%)
		leucine-rich repeat	807..830	CDD:275380	20/22 (91%)
		leucine-rich repeat	831..852	CDD:275380	17/20 (85%)
		PCC	836..>1017	CDD:188093	162/180 (90%)
		leucine-rich repeat	855..867	CDD:275378	11/11 (100%)
		EGF_CA	1002..1038	CDD:238011	33/44 (75%)
		EGF_CA	1042..1077	CDD:238011	29/34 (85%)
		EGF_CA	1080..1116	CDD:238011	29/35 (83%)
		hEGF	1134..1155	CDD:403759	17/20 (85%)
		LamG	1187..1320	CDD:214598	103/132 (78%)
slit2	XP_031751209.1	LRRNT	36..67	CDD:214470	26/30 (87%)
		leucine-rich repeat	46..65	CDD:275380	16/18 (89%)
		LRR_8	64..124	CDD:404697	55/59 (93%)
		leucine-rich repeat	66..89	CDD:275380	20/22 (91%)
		leucine-rich repeat	90..113	CDD:275380	20/22 (91%)
		internalin_A	110..>443	CDD:380193	313/332 (94%)
		leucine-rich repeat	114..137	CDD:275380	20/22 (91%)
		leucine-rich repeat	138..161	CDD:275380	22/22 (100%)
		leucine-rich repeat	162..185	CDD:275380	22/22 (100%)
		LRR_8	163..220	CDD:404697	56/56 (100%)
		leucine-rich repeat	186..209	CDD:275380	22/22 (100%)
		leucine-rich repeat	210..338	CDD:275380	119/127 (94%)
		LRR_8	316..373	CDD:404697	52/56 (93%)
		leucine-rich repeat	339..362	CDD:275380	20/22 (91%)
		leucine-rich repeat	363..383	CDD:275380	18/19 (95%)
		leucine-rich repeat	387..410	CDD:275380	21/22 (95%)
		leucine-rich repeat	411..432	CDD:275380	19/20 (95%)
		PCC	416..>479	CDD:188093	60/62 (97%)
		leucine-rich repeat	435..528	CDD:275380	91/100 (91%)
		internalin_A	492..>864	CDD:380193	344/379 (91%)
		leucine-rich repeat	529..564	CDD:275380	32/34 (94%)
		leucine-rich repeat	565..588	CDD:275380	21/22 (95%)
		leucine-rich repeat	589..612	CDD:275380	19/22 (86%)
		LRR_8	612..671	CDD:404697	54/58 (93%)
		leucine-rich repeat	613..636	CDD:275380	19/22 (86%)
		leucine-rich repeat	637..658	CDD:275380	20/20 (100%)
		leucine-rich repeat	661..783	CDD:275380	112/121 (93%)
		LRR_8	783..842	CDD:404697	55/58 (95%)
		leucine-rich repeat	784..807	CDD:275380	21/22 (95%)
		leucine-rich repeat	808..831	CDD:275380	20/22 (91%)
		leucine-rich repeat	832..853	CDD:275380	17/20 (85%)
		PCC	837..>1018	CDD:188093	162/180 (90%)
		EGF	1007..1034	CDD:394967	25/26 (96%)
		EGF_CA	1052..1087	CDD:238011	29/34 (85%)
		EGF_CA	1090..1126	CDD:238011	29/35 (83%)
		EGF	1139..1168	CDD:394967	23/28 (82%)
		LamG	1197..1330	CDD:214598	103/132 (78%)
		GHB_like	1482..1542	CDD:419725	52/59 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I8366
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3516
Inparanoid	1	1.050	2864	1.000	Inparanoid score	I276
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13455at32523
OrthoFinder	1	1.000	-	-		FOG0001593
OrthoInspector	1	1.000	-	-		oto153991
Panther	1	1.100	-	-	LDO	PTHR45836
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160