Protein Alignment NHERF2 and CG10939

DIOPT Version :10

• Sequence 1: XP_054170405.1
• Gene: NHERF2 / 9351
• HGNCID: 11076
• Length: 360
• Species: Homo sapiens
• Sequence 2: NP_524712.1
• Gene: CG10939 / 44155
• FlyBaseID: FBgn0010620
• Length: 296
• Species: Drosophila melanogaster
• Alignment Length: 376
• Identity: 97/376 - (25%)
• Similarity: 149/376 - (39%)
• Gaps: 118/376 - (31%)

Human     4 PEPLRP---RLCRLVRGE--QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVN 63
            |..|.|   :.|.:|:..  .||||:||.||.:.||||.:|:..||||||.|:.|||::|||||:
  Fly    12 PPTLPPGVTKTCHIVKRPDFDGYGFNLHSEKVKPGQFIGKVDADSPAEAAGLKEGDRILEVNGVS 76

Human    64 VEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHT 128
            :..|||.|||.||||:..:.|||::
  Fly    77 IGSETHKQVVARIKAIANEVRLLLI---------------------------------------- 101

Human   129 GSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPG-QYIRSVDPGSPAARSGLRA 192
                      ||.|...|::|      ..|.....|.:...|:.| :..:...||:.|
  Fly   102 ----------DVDGKALEVKP------ASPPAAACNGNGSASQNGYEGTKQEMPGASA------- 143

Human   193 QDRLIEVNGQNVEGLRHAEVVASIKARE--DEARLLVVDPETDEHFKRLRVTPTEEHVEGPL--- 252
                 .::..::...:.:...:||::..  :.:.|.|||          |..|.   |..|:
  Fly   144 -----NISSISMVSTKRSSNASSIQSGSTMNASDLDVVD----------RGIPA---VAAPVAIT 190

Human   253 PSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEEGPPSGVWDQGS-----------LQTPHPPCS 306
            |.||.||:.|:.....:...|....|.:.|       :|:.:.||           :.||..|..
  Fly   191 PPPVQNGSKPSSPINNNTLMSTPPPPSATK-------AGINNNGSVYNTNGNGTNGMTTPTTPPP 248

Human   307 PQDGSAWKQDPFQESGLHLSPTAAEAKEK-ARAMRVNKRAPQMDWNRKREI 356
            |..|       ::...|||..||||.:.| |...:.:.:...:|..:|.:|
  Fly   249 PTSG-------YKAGTLHLPMTAAEMRAKLASKKKYDPKNESVDLKKKFDI 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NHERF2	XP_054170405.1	PDZ_NHERF-like	10..89	CDD:467249	43/80 (54%)
		PDZ_NHERF-like	150..229	CDD:467249	11/81 (14%)
		EBP50_C	232..360	CDD:462654	33/140 (24%)
CG10939	NP_524712.1	PDZ_NHERF-like	21..102	CDD:467249	43/130 (33%)