Protein Alignment NHERF2 and nrfl-1

DIOPT Version :10

• Sequence 1: XP_054170405.1
• Gene: NHERF2 / 9351
• HGNCID: 11076
• Length: 360
• Species: Homo sapiens
• Sequence 2: NP_741479.1
• Gene: nrfl-1 / 177736
• WormBaseID: WBGene00006438
• Length: 608
• Species: Caenorhabditis elegans
• Alignment Length: 390
• Identity: 101/390 - (25%)
• Similarity: 152/390 - (38%)
• Gaps: 97/390 - (24%)

Human     6 PLRPRLCRLVRG--EQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGET 68
            |..|||..|.:|  :|.:||:||.|:| ||.||..|:.|...|.|.|.||.|:|.|||..:...|
 Worm   279 PYLPRLAELNKGTPDQEFGFNLHAERG-RGHFIGTVDAGGIGEKAGLEAGQRIVGVNGQLIYPTT 342

Human    69 -HHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQR-------GLPPAHDPWE---PK 122
             |.:||..||....:|.|||..::.|:..:...:..:.:..:|       .:...|...|   ||
 Worm   343 GHKEVVALIKKDTMKTTLLVASEDVDKYHKDHNIAYSWDNVERVDTRPVINVETHHHHEEVSVPK 407

Human   123 P---DWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSP 184
            .   |......||.:..::      ||:.......|.       ...::.:...||..|......
 Worm   408 SNGYDVPPLNPHSIQVNEE------REISKMTTTTRT-------ETITNSNSAYQYKESSTAYDA 459

Human   185 AARSGLRAQDRLIEVNGQ-NVEGL---RHAEV---------VASIKAREDEARLLVVDPE----- 231
            .|...:.:.|.:.||.|: |:.|:   .|.||         |:|:.:..:.|..:.|..:
 Worm   460 YATPPVDSNDLMDEVFGRVNLPGVTMSSHTEVLPPTDDISSVSSLSSHRESAVDVPVSHQYVPSY 524

Human   232 -TDEHFKRLRVTPT-EEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEEGPPSGVWD 294
             |:.|.|..:.:.| ..|.:...|||::||:|     .|.|.||.|   |.|.|
 Worm   525 ATESHQKHEQHSQTHHHHHQHQQPSPLSNGSS-----HGYAASSTS---GYDDD----------- 570

Human   295 QGSLQTPHPPCSPQDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSN 359
                                 |.:     |||  |.||:|:.|.........:|..|.|.::.||
 Worm   571 ---------------------DIY-----HLS--AREARERLRMKNRKHHLHEMSLNEKYQLVSN 607

Human   360  359
             Worm   608  607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NHERF2	XP_054170405.1	PDZ_NHERF-like	10..89	CDD:467249	37/81 (46%)
		PDZ_NHERF-like	150..229	CDD:467249	17/91 (19%)
		EBP50_C	232..360	CDD:462654	33/129 (26%)
nrfl-1	NP_741479.1	PDZ_NHERF-like	283..364	CDD:467249	37/81 (46%)