DRSC/TRiP Functional Genomics Resources

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Protein Alignment NHERF2 and Nherf2

DIOPT Version :10

Sequence 1:XP_054170405.1 Gene:NHERF2 / 9351 HGNCID:11076 Length:360 Species:Homo sapiens
Sequence 2:NP_446263.2 Gene:Nherf2 / 116501 RGDID:620380 Length:337 Species:Rattus norvegicus


Alignment Length:360 Identity:309/360 - (85%)
Similarity:322/360 - (89%) Gaps:23/360 - (6%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MAAPESLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65

Human    66 GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGS 130
            ||||||||||||||||||:|||||:||||||.|||||||||||.|||||||:|||||||||.:||
  Rat    66 GETHHQVVQRIKAVEGQTQLLVVDKETDEELCRRQLTCTEEMAHRGLPPAHNPWEPKPDWACSGS 130

Human   131 HSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDR 195
            ..|:.|:|||:||.|||||||||||:|||||||||||||||||||||||||||||:.||||||||
  Rat   131 LGSDTGQKDVNGPPRELRPRLCHLRRGPQGYGFNLHSDKSRPGQYIRSVDPGSPASLSGLRAQDR 195

Human   196 LIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGT 260
            |||||||||||||||||||.|||:||||||||||||||||||||||.|||:||||||||||||||
  Rat   196 LIEVNGQNVEGLRHAEVVARIKAQEDEARLLVVDPETDEHFKRLRVVPTEDHVEGPLPSPVTNGT 260

Human   261 SPAQLNGGSACSSRSDLPGSDKDTEEGPPSGVWDQGSLQTPHPPCSPQDGSAWKQDPFQESGLHL 325
            |.|||||||.||||||||||:||.|                       ||||||:||||||||||
  Rat   261 SLAQLNGGSVCSSRSDLPGSEKDNE-----------------------DGSAWKRDPFQESGLHL 302

Human   326 SPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 360
            |||||||||||||.|||||||||||||||||||||
  Rat   303 SPTAAEAKEKARATRVNKRAPQMDWNRKREIFSNF 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NHERF2XP_054170405.1 PDZ_NHERF-like 10..89 CDD:467249 77/78 (99%)
PDZ_NHERF-like 150..229 CDD:467249 73/78 (94%)
EBP50_C 232..360 CDD:462654 96/127 (76%)
Nherf2NP_446263.2 PDZ_NHERF-like 10..89 CDD:467249 77/78 (99%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 127..146 9/18 (50%)
PDZ_NHERF-like 150..229 CDD:467249 73/78 (94%)
EBP50_C 232..337 CDD:462654 96/127 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..337 83/113 (73%)

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