DRSC/TRiP Functional Genomics Resources

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Protein Alignment NHERF2 and LOC100535100

DIOPT Version :10

Sequence 1:XP_054170405.1 Gene:NHERF2 / 9351 HGNCID:11076 Length:360 Species:Homo sapiens
Sequence 2:XP_021328841.2 Gene:LOC100535100 / 100535100 -ID:- Length:355 Species:Danio rerio


Alignment Length:377 Identity:210/377 - (55%)
Similarity:254/377 - (67%) Gaps:49/377 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     7 LRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQ 71
            |:||||.:.:||.|||||||||||:.||:||:||..|||||:.||||||:|||||.|||.|||||
Zfish     5 LKPRLCVMKKGENGYGFHLHGEKGKTGQYIRKVERASPAEASGLRAGDRVVEVNGENVERETHHQ 69

Human    72 VVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAG 136
            |||||||||.:|||||||:||||..|..:||||||||.|..|.|..| .|.|..:..| :.|.:.
Zfish    70 VVQRIKAVEHETRLLVVDRETDEYFRSLRLTCTEEMAIRTSPTATTP-SPSPSTSKQG-NGSVSK 132

Human   137 KKDVSGPLR-----------------------ELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRS 178
            :.::|.|:|                       ||.||||.|.:...||||||||:||:||||||:
Zfish   133 RSEISKPIRKPPSRALKKDVQPSSESSTRDPSELVPRLCFLVRSDTGYGFNLHSEKSKPGQYIRA 197

Human   179 VDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
            :||||||.|:||:.|||||||||.|:|.:|||||||.||....|.|||||||:||||||::.:||
Zfish   198 LDPGSPADRAGLKPQDRLIEVNGVNIESMRHAEVVAFIKNGGKETRLLVVDPDTDEHFKKMNITP 262

Human   244 TEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEEGPPSGVWDQGSLQTPHPPCSPQ 308
            |..||: .....:|||:|...:||.|:.|:.||  ||.:|.                     :.|
Zfish   263 TSIHVK-DFDESITNGSSSPHVNGTSSRSTHSD--GSSQDN---------------------NVQ 303

Human   309 DGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 360
            ..|:...|||:|:||:||||||||||||.|.|..|||||||||:|.||||||
Zfish   304 YSSSHLLDPFEETGLNLSPTAAEAKEKAHAKRARKRAPQMDWNKKHEIFSNF 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NHERF2XP_054170405.1 PDZ_NHERF-like 10..89 CDD:467249 60/78 (77%)
PDZ_NHERF-like 150..229 CDD:467249 54/78 (69%)
EBP50_C 232..360 CDD:462654 60/127 (47%)
LOC100535100XP_021328841.2 None

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